肠易激综合征患者血清IL-10、IL-12及皮质醇变化及其意义

Changes of Serum Interleukin-10, Interleukin-12 and Cortisol in Patients with Irritable BowelSyndrome

目的:探讨肠易激综合征(IBS)患者血清白细胞介素10(IL-10)、白细胞介素12(IL-12)和皮质醇(CO)浓度变化及它们在IBS中的可能作用和临床意义。方法:随机抽取来源于门诊和住院IBS患者和健康志愿者血清,采用放射免疫法测量血清IL-10、IL-12和CO浓度。结果:腹泻型IBS病人血清IL-10和CO含量显著高于正常(P<0.05),便秘型IBS病人血清内IL-10和CO水平也高于正常对照(P<0.05)。腹泻型和便秘型IBS病人血清内IL-10和CO水平之间差别无统计学意义(P>0.05)。腹泻型IBS组血清IL-12含量比正常组低(P<0.05),便秘型IBS组血清内IL-12水平也低于正常对照组(P<0.05)。腹泻型和便秘型组之间血清内IL-12水平差别无统计学意义(P>0.05)。结论:炎症因子和应激可能参与IBS发病。

Objective： To investigate the changes of serum interleukin 10 （IL-10）, interleukin 12 （IL-12） and cortisol （CO） in patients with irritable bowel syndrome （IBS）. Methods： The serum level of IL-10, IL-10 and CO was measured by radioimmunoassay in controls and patients with IBS randomly selected from outpatients and inpatients. Results： IL-10 and CO was significantly increased in the serum of patients with diarrhea-predominant IBS and constipation-predominant IBS （P〈0.05 vs normal control）. There was no difference of IL-10 and CO level between patients with constipation-predominant IBS and diarrhea-predominant IBS（P〉0.05）. IL-12 was significantly decreased in the serum of patients with diarrhea-predominant IBS and constipation-predominant IBS （P〈0.05 vs normal control）. There was no difference of IL-12 level between patients with constipation-predominant IBS and diarrhea-predominant IBS（P〉0. 05）. Conclusions： Inflammation agents and stress may participate in the pathogenesis oflBS.