CD44V6和MMP-2在甲状腺肿瘤中的表达及其临床意义

Expression and Clinical Significance of CD44v6 and MMP-2 in Benign and Malignant Thyroid Tumors

目的:研究黏附分子CD44V6和基质金属蛋白酶-2(MMP-2)在甲状腺癌中的表达、相互关系及其与甲状腺癌侵袭转移的相关性。方法:采用SP免疫组化法检测114例甲状腺肿瘤组织中CD44V6和MMP-2的表达。结果:CD44V6和MMP-2在35例甲状腺乳头状癌(Papillary Thyroid Carcinoma,PTC)中阳性表达率分别为70.6%和73.5%,在41例甲状腺滤泡癌(Follicular Thyroid Carcinomas,FTC)中阳性表达率分别为70.7%和75.6%,均高于甲状腺腺瘤和结节性甲状腺肿组织中的表达,差异具有统计学意义(P<0.05)。在甲状腺癌组织中MMP-2和CD44V6的表达具有显著相关性(r=0.4828,P<0.001)。且两者表达与甲状腺癌的临床分期及有、无淋巴结转移显著相关。结论:CD44V6和MMP-2的表达与甲状腺癌分化程度、浸润和转移关系密切。CD44V6和MMP-2检测对甲状腺癌的诊断、分化程度、转移趋势和预后评估具有重要参考价值,是甲状腺癌侵袭、转移和预后判断的分子标志物。

Objective： To investigate the relationship between the expression of CD44V6 and MMP-2 and invasion, metastasis in the thyroid carcinoma. Methods： The SP immunohistochemical method was employed to detect the expression of CD44V6 and MMP-2 in 75 cases thyroid carcinomas and 39 cases benign thyroid tumors. Results： The positive expression rate of cd44v6 in Papillary Thyroid Carcinomas and Follicular Thyroid Carcinomas was 70.6%（24/34） and 70.7% （29/41） respectively, while the positive expression rate of MMP-2 in Papillary Thyroid Carcinomas and Follicular Thyroid Carcinomas was 73.5% （25/34） and 75.6%（31/41） respectively, both of which was higher than that in the thyroid adenoma and nodular goiter. The expression of CD44V6 was significantly correlated with the expression of MMP-2 in thyroid carcinoma （γ=0.4828, P〈0.001）, and their expression was significantly correlated with clinical stage and lymph node metastasis. Conclusion： The expression of CD44V6 and MMP-2 is associated with invasion and metastasis of thyroid carcinoma. There are common effects to promote the invasion and metastasis in thyroid carcinoma.