二甲双胍联合妈富隆治疗多囊卵巢综合征32例疗效观察

Efficacy Observations of Dimethyldiguanide Combined with Marvelon in the Treatment of Polycystic Ovary Syndrome

目的观察二甲双胍联合妈富隆对多囊卵巢综合征的治疗效果。方法将多囊卵巢综合征64例随机分为治疗组和对照组,在所有病例均给予妈富隆口服的基础上,治疗组同时加用二甲双胍1500mg/d,治疗6个月。检测患者治疗前后血清内分泌代谢指标,观察月经变化和排卵情况。结果6个月后,两组血清空腹胰岛素水平、雄激素、黄体生成素水平均有不同程度下降,治疗组下降程度明显高于对照组;治疗组总排卵率(75.00%)也高于对照组(46.67%)。结论二甲双胍是一种有效的治疗多囊卵巢综合征的药物。

Objective To investigate the effect of dimethyldignanide combined with marvelon on patients with polycystic ovary syndrome （PCOS）. Methods 64 cases of polycystic ovary syndrome patients were divided into treatment group and control group. Marvelon treatments were given to both groups, while extra dimethyldiguanide treatment was given to the treatment group, giving dimethyldignanide 1500 mg per day for six months ; Detection of endocrinal markers was given before and after treatment with drawal of mefformin. Themenses and ovulation were observed. Results There was a decrease of the serum levels of fasting insulin,T and LH after 12 weeks of treatment in the two groups,more significant in observation group compared to that of control groups（ P 〈 0.05 ）. The total effective rate of ovulation of the treatment group was 75 percent and the control group was 46.67 percent,significantly higher efficacy in the treatment group（P 〈 0.05）. Conclusion Dimethyldignahide is an effective drug for PCOS.