期刊文献+

二甲双胍联合妈富隆治疗多囊卵巢综合征32例疗效观察 被引量:4

Efficacy Observations of Dimethyldiguanide Combined with Marvelon in the Treatment of Polycystic Ovary Syndrome
下载PDF
导出
摘要 目的观察二甲双胍联合妈富隆对多囊卵巢综合征的治疗效果。方法将多囊卵巢综合征64例随机分为治疗组和对照组,在所有病例均给予妈富隆口服的基础上,治疗组同时加用二甲双胍1500mg/d,治疗6个月。检测患者治疗前后血清内分泌代谢指标,观察月经变化和排卵情况。结果6个月后,两组血清空腹胰岛素水平、雄激素、黄体生成素水平均有不同程度下降,治疗组下降程度明显高于对照组;治疗组总排卵率(75.00%)也高于对照组(46.67%)。结论二甲双胍是一种有效的治疗多囊卵巢综合征的药物。 Objective To investigate the effect of dimethyldignanide combined with marvelon on patients with polycystic ovary syndrome (PCOS). Methods 64 cases of polycystic ovary syndrome patients were divided into treatment group and control group. Marvelon treatments were given to both groups, while extra dimethyldiguanide treatment was given to the treatment group, giving dimethyldignanide 1500 mg per day for six months ; Detection of endocrinal markers was given before and after treatment with drawal of mefformin. Themenses and ovulation were observed. Results There was a decrease of the serum levels of fasting insulin,T and LH after 12 weeks of treatment in the two groups,more significant in observation group compared to that of control groups( P 〈 0.05 ). The total effective rate of ovulation of the treatment group was 75 percent and the control group was 46.67 percent,significantly higher efficacy in the treatment group(P 〈 0.05). Conclusion Dimethyldignahide is an effective drug for PCOS.
作者 周霞 张进聪
出处 《中国现代医生》 2009年第9期28-29,共2页 China Modern Doctor
关键词 二甲双胍 多囊卵巢综合征 胰岛素抵抗 Dimethyldiguanide Polycystic ovary syndrome Insulin resistance
  • 相关文献

参考文献7

二级参考文献33

  • 1Haffner SM,Kennedy E,Gonzalez C,et al.A prospective analysis of the Homa model.The Mexico city diabetes study.Diabetes Care,1996,19:1138-1341
  • 2Moran C,Huerta R,Conway-Myers BA,et al.Altered autophosphorylation of the in sulin receptor in the ovary of a women with polycystic ovary syndrome.Fertil Steril,2001,75:625-628
  • 3Murakawa H,Hasegawa I,Kurabayashi T,et al.Polycystic ovary syndrome insulin resistance and ovulatory responses to clomiphene citrate.J Reprod Med,1999,44: 23-27
  • 4Mitwally MF,Kuscu NK,Yalcinkaya TM.High ovulatory rates with use of troglitaz one in clomiphene-resistant women with polycysticovary syndrome.Hum Reprod,199 9,14:2700-2703
  • 5Elazquez EM,Mendoza S,Hamer T,et al.Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia,insulin resistance,hyperandrogenemia,and systolic blood pressure,while facilitating normal menses and pregnancy.Metabolism,1994,4 3:647-654
  • 6Moghetti P,Castello R,Negri C,et al.Metformin effects on clinical fea tures,e ndocrine and metabolic profiles and insulin sensitivity in polycystic ovary synd rome:a randomized double-blind,placebo-controlled 6-month trial,followed by open long-term clini
  • 7Ng EH,Wat NM,Ho PC.Effects of metformin on ovulation rate,hormonal and meta bolic profiles in women with clomiphene-resistant polycystic ovaries:a randomized,double-blind placebo-controlled trial.Hum Reprod,2001,16:1625-1631
  • 8Morin-Papunen LC,Koivunen RM,Ruokonen A,et al.Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome.Fertil Steril,1998,69:691-696
  • 9Berger J,Baile P,Biswas C,et al.Thiazolidinediones produce a conformational change in peroxisomal proliferators activated receptergamma;binding and activati on correlate with antidiabetic actions in db/db mice.Endocrinology,1996,137:41 89-4195
  • 10Ehrmann DA,Schneider DJ,Sobel BE,et al.Troglitazone improves defects in insulin action,insulin secretion,ovarian steroidogenesis,and fibrinolysis in women with polycystic ovary syndrome.J Clin Endocrinol Metab,1997,82:2108-2116

共引文献56

同被引文献17

引证文献4

二级引证文献21

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部