摘要
利用PC12细胞氧化应激损伤模型，对6种药用真菌的49个脂溶性提取物进行筛选，研究表明，灵芝等药用真菌均具有氧化应激保护作用，其中桑黄和北虫草活性显著。29个样品在5～150mg／L对PC12氧化应激损伤的保护作用呈剂量依赖性增长。药用真菌脂溶性提取物对PC12细胞氧化应激损伤保护作用与药用真菌的种类密切相关，并且药用真菌的不同菌株对PC12细胞氧化应激损伤保护作用也是不同的。
The screening test for 49 lipophilic extracts of 6 medicinal fungi by using the oxidativestress damage model of PC12 cells showed that all the 6 medicinal fungi had a protective role against the oxidative-stress damage. The activities of Phellinus linteus and Cordyceps militaris were significant. The protective effects of the 29 samples between 5-150 mg/L against the oxidative-stress damage presented a dose-dependent growth. The protective effect of lipophilic extracts of medicinal fungi against the oxidative-stess damage in PC12 cells was closely related to the medicinal fungi＇s species, and different stains of the same medicinal fungus had a different protective effect against the oxida- tive-stress damage.
出处
《上海农业学报》
CSCD
北大核心
2009年第1期9-13,共5页
Acta Agriculturae Shanghai
基金
上海市科技兴农重点攻关项目[沪农科攻字(2002)第1-4-3号]资助
关键词
药用真菌
脂溶性提取物
氧化应激
PC12
保护作用
Medicinal fungi
Lipophilic extracts
Oxidative-stress damage
PC12 cell
Protective effect
