盐酸米诺环素辅助治疗慢性牙周炎的疗效观察

The Adjunctive Clinical Benefits of Minocycline in the Treatment of Chronic Periodontitis

目的观察局部应用盐酸米诺环素辅助治疗慢性牙周炎的临床疗效.方法将30例患慢性牙周炎病例的患牙120个随机分成4组:(1)盐酸米诺环素+刮治及根面平整术组;(2)单纯刮治及根面平整术组;(3)单纯用米诺环素组;(4)未处理组.分别在基线、1周,4周时检测菌斑指数(P)I、牙龈指数(G)I,探诊出血指数(BOP)、探诊深度(PD)、附着丧失(AL)等牙周病临床指标.结果盐酸米诺环素+刮治组在1周和4周时探诊深度和探诊出血率显著低于其它3组(P<0.05).结论龈下局部应用米诺环素联合刮治术及根面平整术在降低探诊深度和探诊出血方面比单纯实施刮治术的效果明显.

Objective To evaluate the adjunctive clinical benefits of minocycline in the treatment of chronic periodontitis. Methods 120 teeth in 30 patients with chronic periodontitis were randomly divided into four groups： （1） minocycline plus scaling and root planning; （2） scaling and root planning alone; （3） minocycline alone; （4） untreated group. All parameters including plaque index （PI） , gingival index （GI） , bleeding on probing （BOP） , probing depth （PD） and attachment loss （AL） were measured at baseline and, 1 and 4 weeks after treatment. Result Minocycline plus scaling and root planning group resulted in a significant reduction in PD and in BOP rate compared to the other three groups （P 〈 0.05）. Conclusion Sub-gingival minocycline plus scaling and root planning has more significant effectin in PD and BOP reduction than scaling and root planning alone, therefore, minocycline plus scaling and root planning can be effectively used in the treatment of chronic periodontitis.