微创血肿抽吸治疗对脑出血兔神经元特异性烯醇化酶的影响

Effect of minimally invasive hematoma stereotactic aspiration therapy on serum neuron specific enolase in cerebral hemorrhage

目的探讨微创血肿抽吸治疗脑出血兔神经元特异性烯醇化酶(NSE)含量变化在预后评估中的价值。方法分别进行血肿体积、Zea Longa评分、血清NSE浓度检测。结果①与对照组比较治疗组在治疗后3、7d血肿体积明显缩小(P<0.001),神经功能缺失体征评分差异显著(P<0.05);②与对照组比较,治疗组治疗后3、7d血清NSE水平显著降低(均P<0.001);③血清NSE浓度既与血肿体积呈正相关,也与预后呈正相关。结论早期微创血肿抽吸治疗可显著降低血肿体积和血清NSE水平,改善预后。提示NSE是预测早期神经功能损害和恢复的可靠指标。

Objective To investigate effect of minimally invasive hematoma stereotactic aspiration therapy on serum neuron specific enolase （NSE） in cerebral hemorrhage. Methods Hematoma volume, Zea Longa score and serum NSE level were detected. Results Compared with control group, hematoma volume, signals of neurological functional deficit score and serum NSE level had obvious difference in treatment group on the third and 7th day （P 〈0.05, P 〈0. 001 ）. Serum NSE level had positive correlation not only with hematoma volume also with prognosis. Conclusions Early minimally invasive hematoma stereotactic aspiration therapy can decrease hematoma volume and NSE level obviously and improve prognosis, which suggest NSE would be a reliable index to predict early neurological functional deficit and recovery.