年龄对正常成年人视网膜神经纤维层厚度的影响(英文)

The influence of age on retinal nerve fiber layer thickness in adults

目的使用偏振激光扫描仪对部分健康的中国成年人视网膜神经纤维层(RNFL)厚度进行测定,评估年龄和RNFL厚度之间的关系。方法使用GDxVCC神经纤维分析仪的两种不同检测模式(可变角膜补偿,VCC;强化角膜补偿,ECC)测定150例患者共150眼的视网膜神经纤维层厚度。测量参数包括:颞侧-上方-鼻侧-下方-颞侧平均(TSNITave)、上方平均(Superiorave)、下方平均(Inferiorave)、TSNIT标准差(TSNITstdDev)、和神经纤维指数(NFI)。结果VCC检测模式得到的TSNITave、Superiorave、Inferiorave、TSNITstdDev、NFI平均值分别为(57.12±6.26),(69.35±4.21),(67.59±7.06),(25.46±4.02),(17.35±7.59)。ECC检测模式五项检测值分别为:(56.15±5.32),(68.24±6.63),(66.90±2.40),(24.80±6.76),(18.84±8.51)。VCC和ECC模式的检测值之间的差异不具统计学意义。在总样本人群中检测参数指标与年龄存在统计学意义的相关性。而在40岁以上人群中检测参数指标与年龄未发现相关性。结论VCC和ECC模式对检测150例正常国人视网膜神经纤维层厚度的检测值之间不存在统计学差异。对21～70岁的健康人眼中,RNFL厚度检测值随年龄增长而变薄,但在40岁以上人群中未见此改变。

Objective To evaluate the association of age and retinal nerve fiber layer （RNFL） thickness by means of scanning laser polarimetry in a sample of healthy Chinese eyes. Methods One hundred and fifty eyes of 150 healthy subjects underwent RNFL scan in two different modes （Variable Cornea Compensation, VCC; Enhanced Cornea Compensation, ECC） of Glaucoma Diagnosis Variable Cornea Compensation Nerve Fiber Analyzer. The parameters included temporal-superior-nasal-inferiortemporal （TSNIT） average, superior average, inferior average, TSNIT standard deviation, and nerve fiber indicator （NFI）. Results Mean values of TSNIT average, superior average, inferior average, TSNIT standard deviation and NFI in VCC mode were （57. 12 ±6. 26）, （69. 35 ± 4. 21）, （67.59 ± 7. 06） ,（25.46±4.02）,（17.35±7.59）,while the parameters＇ values in ECC mode were （56. 15± 5.32 ）, （68.24 ± 6.63 ）, （66.90± 2.40 ）, （24.80± 6.76 ）, （ 18.84 ± 8.51 ）, respectively. The differences between the values of VCC and ECC modes were not statistically significant. The parameters＇ values of total subjects were associated with age. But there were no significant associations between age and parameter values in the eyes of those older than 4{） years old subjects. Conclusions There are no significant differences between the RNFL values detected by VCC and ECC modes in 150 healthy Chinese eyes. Age has influence on RNFL thinning in 21-70 years old healthy eyes, but not in the eyes of older than 40 years old people.