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DNA甲基化和miRNA在胶质瘤中的研究进展 被引量：3

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摘要 DNA甲基化、微RNA(miRNA)在胶质瘤的发生、发展中起重要作用。多条癌症通路相关基因启动子区域的CpG岛甲基化发生频率与胶质瘤的发生与发展、组织类型和病理分级密切相关。miRNA的异常表达通过调控靶向基因、作用于癌症相关通路及脑肿瘤干细胞等机制扮演着抑癌或致癌角色。而miRNA的表达也受到甲基化的调控,这对综合评价肿瘤的发生、发展具有重要的意义。本文即对这两者在胶质瘤中的作用机制进行综述。
作者 李庆斌 张伟 江涛 蒋传路
机构地区 哈尔滨医科大学第二临床医学院神经外科 首都医科大学附属天坛医院胶质瘤治疗中心
出处 《中国微侵袭神经外科杂志》 CAS 北大核心 2009年第3期142-144,共3页 Chinese Journal of Minimally Invasive Neurosurgery
基金 "十一五"国家科技支撑计划资助项目(编号:2007BAI05B08) 国家自然科学基金资助项目(编号:30772238)
关键词 神经胶质瘤 DNA甲基化 微RNAS
分类号 R739.4 [医药卫生—肿瘤]
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参考文献18

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同被引文献96

  • 1纪长伟,贾立敏,倪秀芹,鲍淑梅,朱保国.E-cadherin、MCP-1和MIP-1β在B16黑色素瘤荷瘤鼠中的表达及意义[J].中国现代医学杂志,2008,18(21):3103-3106. 被引量：3
  • 2夏丹,范伟.DNA甲基化与肿瘤相关性研究进展[J].中国误诊学杂志,2009,9(6):1275-1276. 被引量：6
  • 3JingDeZHU.The altered DNA methylation pattern and its implications in liver cancer[J].Cell Research,2005,15(4):272-280. 被引量：17
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  • 6Honardoost MA, Kiani-Esfahani A, Ghaedi K, et al. miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing-remitting multiple sclerosis [ J ]. Gene,2014,544 (2) : 128 - 133.
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中国微侵袭神经外科杂志
2009年 第3期

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