髓过氧化物酶基因多态性与原发性高血压遗传易感性的研究

Gene polymorphism of myeloperoxidase and genetic susceptibility to essential hypertension

目的:研究髓过氧化物酶(MPO)基因多态性与原发性高血压(EH)之间的遗传易感性。方法:采用分子流行病学方法,应用聚和酶链反应检测法107例EH和97例健康对照MPO基因型,比较不同基因型之间的分布频率及95%可信区间(CI),分析MPO基因多态性与EH易感性的关系。结果:正常人群GG、GA、AA基因型频率分别为56.7%、40.2%和3.1%,EH组分别为70.1%、29.0%和0.9%。携带GG者患EH的风险是基因型为至少一个等位基因A者的1.79倍(95%CI1.005～3.186)。结论:本研究人群MPO基因多态与EH遗传易感性相关,等位基因A对EH易感性有保护作用。

Objective： To investigate the association between gene polymorphism of myeloperoxidase and genetic susceptibility to essential hypertension in Chinese population. Method： MPO genotypes in 107 cases of essential hypertension and 97 persons of healthy control were detected using PCR-restriction fragment length polymorphism assay （PCR RFLP） in a case control molecular epidemiology study. The association between this gene polymorphism and the risk of essential hypertension in Chinese population was examined through comparing odds ratio （OR） and 95 confidence interval （CI） between two groups. Result： In healthy control group, the frequencies of G/G, G/A, and A/ A genotypes were 56. 7 %,40.2 % and 3.1 %, respectively. In essential hypertension group, the frequencies of the persons carrying above three genotypes were 70.1 %, 29.0 % and 0.9 %, respectively. The risk of Essential Hypertension for person carrying G/G genotype was 1.79 fold of the persons carrying at least one A allele （95% CI 1. 005- 3. 186）. Conclusion： MPO gene polymorphism was associated with susceptibility of essential hypertension in Chinese population. The risk of essential hypertension was decreased in the persons carrying allele A.