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组织型激肽释放酶对脑缺血大鼠神经和血管的影响 被引量：2

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摘要 目的探讨组织型激肽释放酶(tissue kallikrein,TK)对脑缺血再灌注大鼠治疗作用和对神经再生和血管再生的影响。方法将36只SD大鼠随机分为3组:假手术组,生理盐水干预组(NS2 mL.kg-1.d-1);TK组(TK17.5×10-3U.kg-1.d-1)。药物在缺血后8 h给予,连续用药3 d。3 d后分别进行神经功能缺失评分,脑梗死体积测定,梗死组织HE染色。对脑缺血组织进行神经元烯醇化酶(neuron specific enolase,NSE)、神经胶质纤维酸性蛋白(glial fibrillary acidic protein GFAP)、假性血友病因子(von Wille-brand factor vWF)免疫组化检测。结果TK治疗3 d后,与生理盐水干预组相比,能明显降低神经功能缺失(P<0.05),脑梗死的体积(P<0.05);减轻脑梗死的病理改变。使缺血区内NSE、GFAP、vWF阳性细胞表达增多(P<0.05)。结论TK对脑缺血再灌注大鼠有治疗作用,能明显增加脑缺血区内的神经再生和血管再生。
作者 倪耀辉 丁素菊
机构地区 第二军医大学附属长海医院 南通大学附属医院
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2009年第3期173-175,共3页 Chinese Journal of Nervous and Mental Diseases
关键词 组织型的激肽释放酶 脑缺血再灌注 治疗作用 神经再生 血管再生
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献16

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共引文献95

同被引文献41

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中国神经精神疾病杂志
2009年 第3期

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