外伤性脑梗死患者P选择素动态检测的临床意义

Clinical Significance of Dynamic Detection of Plasma P-selectin in the Patients with Traumatic Cerebral Infarction

目的:研究外伤性脑梗死患者血小板P选择素动态变化的临床意义。方法:用流式细胞仪测定42例外伤性脑梗死患者,50例无脑梗死外伤患者及40例正常对照者外周血血小板P选择素。结果:急性期(1周内)外伤性脑梗死患者P选择素明显高于无梗死脑外伤患者和健康对照组(P<0.01)。14 d时,外伤性脑梗死患者血小板P选择素表达,与无梗死脑外伤患者和健康对照组无显著差异(P>0.005)。结论:P选择素参与外伤性脑梗死的病理过程,测定它们有利于外伤性脑梗死的早期诊治,改善预后。

Objective： To investigate the dynamic change of plasma P-selectin in the patients with traumatic cerebral infarction. Methods： The plasma P-selectin levels in 42 patients with traumatic cerebral infarction, 50 craniocerebral traumatic patients without cerebral infarction and 40 normal controls by flow cytometry. Results：The plasma P-selectin levels in patients with traumatic cerebral infarction were significantly higher than craniocerebral traumatic patients without cerebral infarction and normal control during acute phase （within 1 weeks） （P〈0.01）. There was no significant deviation between the patients with traumatic cerebral infarction and craniocerebral traumatic patients without cerebral infarction and normal controls in the plasma P-selectin levels in the 14th day （P〉0. 005）. Conclusion：P-selectin participates in the pathological process of traumatic cerebral infarction. Detection of plasma P-selectin is valuable to early diagnosis and improvement of their prognosis.