右心房注射前列腺素E_2对新生大鼠呼吸的影响

The Effect of Right Atrial Injection of PGE_2 on Respiration in Neonatal Rats

目的：探讨在不同年龄SD大鼠右心房注射前列腺素E2（PGE2）对呼吸的影响。方法：7～9d和21～23d大鼠在迷走神经完整和迷走神经切断的情况下从右心房注射PGE2，观察呼吸指标的变化。结果：①右心房注射PGE2在7～9d和21～23d大鼠中均引起呼吸暂停，呼气延长时间分别为基础呼气时间的9．5和7．5倍（P〈O．05）；②切断迷走神经后，右心房注射PGEz在7～9d和21～23d大鼠均不再产生呼吸暂停，仅出现轻微呼吸抑制。结论：右心房注射PGE2在7～9d和21～23d大鼠均产生呼吸暂停，且依赖于迷走神经的完整性。

Objective：To compare the effect of right atrial injection of prostaglandin E2 （PGE2）on respiratory response in Sprague-Dawley rats of 7-9 and 21-23 days. Methods： Sprague-Dawley rats at postnatal day 7-9 （P7- 9） and 21-23 （P21 - 23）with intact or transection of bilateral vagal nerves received bolus PGE2 from the right atrium. The ventilatory alterations were compared between two groups. Results： ①Right atrial bolus injection of PGE2 generated apnea in P7-9 and P21-23 rats,which was indicated by prolonging expiration time（TE）about 9.5 and 7.5 fold, respectively（P〈0.05）. ②After transection of bilateral vagal nerves, the PGE2 did not induce apnea in both groups, but generated light breathing inhibition. Conclusion：Right atrial injection of PGE2 induces prolonged apnea in neonatal and weaning rats,which is vagally dependent.