原发和复发乳腺癌体外化疗药物敏感性的量效关系研究

In Vitro Chemosensitivity Test of Primary and Recurrent Breast Cancer

目的:通过体外研究探讨化疗剂量对乳腺癌治疗效果的影响。方法:通过手术取材和肿瘤组织原代细胞体外培养技术,对96例乳腺癌患者进行体外药物敏感性检测。结果:乳腺癌晚期患者比早期患者的耐药风险明显增加(P<0.05),乳腺癌复发患者比原发患者具有更强的多药耐药能力(P<0.01);增加化疗药物剂量仍然可以提高大多数耐药患者的治疗效果(P<0.01)。结论:大剂量化疗方案对晚期和复发性乳腺癌患者有帮助。

Objective：To know the influence of dosage of chemotherapy drug on therapeutic efficacy of breast cancer. culture of tumor cells. Results： Although advanced and relapsed breast cancer patients had stronger ability of drug-resistance （P〈0.01）, buildup of chemotherapeutic dosage could raise their therapeutic efficacy （P〈 0.01 ）. Conclusion：Advanced and relapsed breast cancer patients would benefit from high dose chemotherapy （HDC） regimens.