糖皮质激素及免疫抑制剂致慢性乙肝复发和加重的7例临床分析

Clinical Analysis of 7 Cases with Chronic Hepatitis B Relapse and Exacerbations Caused by Corticosteroids and Immunosuppressant Reactivation

目的:探讨激素及免疫抑制剂导致乙肝病毒再激活所致的肝损害的危害性及治疗效果,指导临床治疗。方法:总结本院近2年收治的7例慢性乙肝病毒感染者在使用激素及免疫抑制剂致肝炎再激活并加重患者的临床资料进行分析。结果:慢性乙肝病毒感染者因各种原因使用激素及免疫抑制剂所导致的慢性乙肝的复发加重,病情发展迅速,病死率高。结论:抗乙肝病毒治疗是预防肝病复发并恶化的关键,在激素或免疫抑制剂治疗前和治疗中都应使乙肝病毒降至尽可能低的水平。

Objective：To detect the perniciousness and outcome of severe hepatitis caused by cortiscosteriods and immunosuppressant reactivation,and to guide clinical care. Methods：Clinical data of 7 severe hepatitis patients were collected and analyzed. Results：The conditon of severe hepatitis caused by corticosteriods and immunosuppressant reactivation deteriorated rapidly and mortality is high in these patients. The key treatment is anti-HBV therapy to prevent the disease deterioration. Conclusion：The level of HBV-DNA must be decreased to the greatest extent before and in the treatment of corticosteriods or immunosuppressant.