喉巨细胞瘤的临床病理分析

Clinicopathological Analysis of Larynx Giant Cell Tumor

目的:探讨喉巨细胞瘤的临床病理学特征及诊断、鉴别诊断要点。方法:报道1例喉巨细胞瘤,结合文献对其临床表现、影像学情况、病理形态学特点及鉴别诊断进行分析和探讨。结果:巨细胞瘤好发于长骨末端,约5%累及扁骨,不足5%的病例累及手足部的短管状骨,2%发生于头颈部。喉巨细胞瘤极罕见,发病平均年龄为42.4岁,男性多见。本例34岁,男性,左侧声门下3 cm×2 cm×2 cm肿块。镜下表现为圆形、卵圆形单核细胞及均匀分布其间的破骨细胞样巨细胞混合组成。结论:喉巨细胞瘤罕见,临床易误诊为恶性肿瘤,其病理学检查有特征性形态改变,结合影像学改变,可以确诊。

Objective：To observe the characteristics of giant cell tumor of the larynx （GCTL） in clinical pathology, diagnosis and differential diagnosis. Methods： A new case of GCTL is presented. The clinical symptoms, radiographic findings,histopathologic findings and differential diagnosis are analyzed together with the cases previously reported. Results：Approximately 2 % of all giant cell tumor arise in the head and neck region,developing mainly at the end of the long bones. The occurrence percentage at flat bones is around 5% while less than 5% at the short tubular bones of hand and foot. GCTL is rare. Its average age is 42.4 and it mainly occurred in the male patients. This case is a man of 34 years-old who has a 3 cm×2 cm×2 cm tumor mass under the left glottis. Microscopically, the tumor consists of round and ovoid monocytes and equally distributed osteoclast-like giant cells. Conclusion： GCTL are rare and likely to be mistaken as malignant clinically. Identification usually can be confirmed by pathologic and radiographic investigations.