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血管内皮生长因子和Ⅳ型胶原在IgA肾病中表达变化的临床意义 被引量:2

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摘要 本研究采用免疫组化SP法观察45例不同病理学分级的IgA肾病(IgAnephropathy,IgAN)患者肾组织中血管内皮生长因子(VEGF)与Ⅳ型胶原(collagen Ⅳ,Col—Ⅳ)表达变化及其与IgAN患者临床指标的关系,以探讨VEGF和Col—Ⅳ在IgAN发展中的致病作用。
出处 《临床肾脏病杂志》 2009年第3期127-128,F0002,共3页 Journal Of Clinical Nephrology
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参考文献7

  • 1Kim BS, Goligorsky MS. Role of VEGF in kidney development, microvascular maintenance and pathophysiology of renal disease. Korean J Intern Med, 2003,18 : 65-75.
  • 2师锁柱,陈香美,张雪光,吴杰,冯全洲,王兆霞.IgA肾病患者血管内皮细胞生长因子及其受体的表达[J].中华内科杂志,2003,42(4):218-218. 被引量:13
  • 3Maruyama K, Tomizawa S, Shimabukuro N, et al. Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries. Nephron, 1989,51: 73- 76.
  • 4Wu Q,Jinde K, Nishina M, et al. Analysis of prognostic predictors in idiopathic membranous nephropathy. Am J Kidney Dis, 2001,37:380- 387.
  • 5Kaneko Y, Nakazawa K, Higuchi M, et al. Glomerular expression of alpha-smooth muscle actin reflects disease activity of IgA nephropathy. Pathol Int,2001 ,51:833-844.
  • 6Ameraiya T, Sasamura H, Mifune M, et al. Vascular endothelial growth factor activates MAP kinase and enhances collagen synthesis in human mesangial cells. Kidney Int, 1999,56: 2055-2063.
  • 7Wada J,Sugiyama H, Makino H, Pathogenesis of IgA nephropathy. Semin Nephrol, 2003,23 : 556-563.

二级参考文献2

  • 1Kang DH,Anderson S,Kim YG,et a1.Impaired angiogenesis in the aging kidney:vascular endothdial growth factor and thrombospondin-1 in renal disease.Am J Kidney Dis,2001,37:601-611.
  • 2Amemiya T,Sasamura H,Mifune M,et a1.Vascular endothelial growth factor activates MAP kinase and enhances collagen synthesis in human mesangial cells.Kidney Int,1999,56:2055-2063.

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