摘要
乙型肝炎的发病机制主要是机体清除乙肝病毒(hepatitis B virus,HBV)而引发的细胞免疫损伤.机体产生的针对HBV的细胞毒性T细胞(cytotoxic T cell,CTL)在病毒清除及肝细胞损伤方面均起关键作用.CD8+CTL是CTL的主要功能亚群,他们通过细胞毒机制和非细胞毒机制清除病毒.在急性自限性HBV感染时,CTL应答呈多克隆性和多特异性,能够及时清除病毒;而在慢性HBV感染时,CTL应答呈单克隆性和寡特异性,导致HBV持续感染.慢性HBV感染可能与CD8+CTL数量不足及功能缺陷有关.
The cellular immune response is thought to play a critical role in viral clearance and disease pathogenesis during HBV infection. Cytotoxic T-lymphocytes （CTLs） response to HBV plays a key role in the viral clearance and liver cell injuries. As a main subpopulation of CTL, CD8＋CTL can eliminate viral through cytotoxic mechanism and non-cytotoxic mechanism. In acute hepatitis B, the CTL response is polyclonal and multispecific, which can eliminate the virus in time; but the CTL response is monoclonal and monospecific in chronic HBV infection, which causes persistent HBV infection. This may be concerned with the dysfunction and insufficiency of the CD8＋CTL.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第4期384-388,共5页
World Chinese Journal of Digestology
