米尔维林合成工艺的研究

Study on Synthesis Technology of Milverine

以苯甲醛为起始原料,经过缩合、加成、氯代、取代、还原、成盐6步反应得到米尔维林。通过改变结晶溶剂工艺,总收率由30.4%提高到35%。

Benzaldehyde was used as the starting material .Milverine was obtained from 6 steps, as follows condensation reaction, addition reaction, chlorination reaction, reduction reaction, salt-formation reaction. The total yield of the technology increased from 30.4% to 35% by changing the solvents of the crystallizations.