中药配合有氧运动疗法对脂肪肝影响机制的实验研究

Experiment study of TCM coordinate with aerobic exercise therapy on fatty liver disease

目的探讨中药配合有氧运动疗法防治脂肪肝的作用机制。方法选用Wistar大鼠随机分为空白、造模、中药、运动、联合五组;空白组普通喂养,造模及其他组给予高脂饲料喂养;中药组与联合组每日灌胃中药健肝汤10 ml/(kg.d)(含生药1.5 g/ml),空白组、造模组、运动组每日等量生理盐水灌胃;运动组、联合组每日有氧运动(游泳)1 h;8周后各组大鼠股动脉取血送检生化指标,处死后测肝脏湿重,计算肝指数。结果联合组可明显降低大鼠血清总胆固醇(TC)、甘油三酯(TG)、丙氨酸转氨酶(ALT)、门冬氨酸氨基转氨酶(AST)水平,且与造模组相比具有非常显著性差异(P<0.01)。结论中药配合有氧运动疗法可有效防治脂肪肝。

Objective To investigate the active mechanism of prevention and cure of TCM combined with aerobic exercise therapy to fatty liver disease. Methods The Wistar rats were divided into 5 groups randomly： Blank group has common feeding and others were fecded food with high fat; TCM group and Combination group were lavaged Jiangantsng physic liquor （contain crude drug 1.5 g/ml ） 10ml/（ kg ·d ） ,the others were lavaged equivalent NS, Sports group and Combination group have aerobic exercise one hour everyday. All the rats were executed in 8 weeks, the blood of every groups was analysed, and the wet weight was measured also to calculate the liver index. Results The levels of TC, TG,ALT lAST in serum of Combination group were more lower than those of model group ,and the difference was very significant. Conclusion TCM combined with aerobic exercise therapy has effect of prevention and cure on fatty liver disease.