胰岛素强化治疗2型糖尿病的2种方案评价探讨

Clinical study of continuous subcutaneous insulin infusion and multiple deliver insulin of the intensive insulin treatment of type 2 diabetes

目的分别采用胰岛素泵(CSⅡ)、多次皮下注射胰岛素(MDI)方法强化治疗2型糖尿病,评价其临床疗效。方法将53例2型糖尿病患者随机分为CSⅡ组20例、MDI组33例,均连续治疗2周。比较2组治疗前后体质量、血糖、糖化血红蛋白、空腹胰岛素、C肽、胰岛素用量、血糖达标时间、低血糖发生率及胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(IAI)。结果CSⅡ组胰岛素用量少,HOMA-IR降低明显,IAI明显增加,低血糖发生率低,体质量增加少。结论CSⅡ强化治疗2型糖尿病优于MDI。

Objective To evaluate the effect of continuous subcutaneous insulin infusion（CS Ⅱ） and multiple deliver insulin on type 2 diabetes patients. Methods 53 patients with type 2 diabetes mellitus（T2DM） were divided into 2 groups randomly ： CS Ⅱ （ n = 20） ; multiple deliver insulin（MDI） （ n = 33）. The leves of blood glucose, HbAic, therapeutic time, amount of insulin, Fins, C-P , body weight,HOMA-IR and IAI were compared among two groups before and after 2 weeks of treatment. Results After treatment, compared with multiple deliver insulin group the CS Ⅱ group had lower levels of insulin amount and body weight,showed the decreased HOMA-IR and increased IAI. Conclusion CSIIis better to improve the blood glucose and insulin resistance obviously.