期刊文献+

喘可治注射液联合布地奈德治疗支气管哮喘疗效观察 被引量:7

Observation of curative effect of Budesonide combined with Chuankezhi injection on bronchial asthma
下载PDF
导出
摘要 目的观察喘可治注射液联合布地奈德治疗支气管哮喘的临床疗效。方法选择我院2006年11月-2008年11月确诊为支气管哮喘患者104例,随机分为2组,各52例。治疗组52例,常规吸入布地奈德的基础上,加用喘可治注射液;对照组52例,仅给予布地奈德吸入治疗。2组在治疗过程中如合并呼吸道细菌感染,加用抗生素。有哮喘急性发作,可加用β2受体激动剂。观察2组治疗前后夜间憋醒天数、哮喘急性发作的天数、β2受体激动剂应用天数及肺功能情况。结果治疗组总有效率为90.4%,对照组总有效率为69.2%。2组比较差异有统计学意义(P<0.05)。结论喘可治注射液联合布地奈德治疗效果较常规疗效好,可作为糖皮质激素的补充治疗。 Objective To observe the curative effect of Budesonide combined with Chuankezhi injection on bronehial asthma. Methods 104 patients with bronchial asthma diagnosed in 2006 -2008 were randomly selected and divided into 2 groups. 52 eases in the treatment group were treated with Chnankezhi injection on the basis of Budesonide, while 52 eases in the control group were treated with Budesonide. Then improvement of symptom and eorrelative indexes were ovserved before and after treatments. Results The total effective rate in the treatment group was 90.40% versus 69.2% in the control group, and the difference was signifieant( P 〈 0.05 ). Conclusion In comparison with routine treatment, Budesonide combined with Chuankezhi injection has a better effeet on bronchial asthma as a supplementary therapy of glueoeortieoid.
作者 吴胜积
出处 《临床合理用药杂志》 2009年第5期14-15,共2页 Chinese Journal of Clinical Rational Drug Use
关键词 支气管哮喘 布地奈德 喘可治 Bronchial asthma Budesonide Chuankezhi injection
  • 相关文献

参考文献2

二级参考文献35

  • 1Fregonese L, Silvestri M, Sabatini F, et al. Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a Cys-LTI receptor mediated mechanism. Clin Exp Allergy, 2002, 32: 745-750.
  • 2Braccioni F, Dorman SC, O′ byrne PM, et al. The effect of cysteinyl leukotrenes on growth of eosinophil proge from peripheral blood and bone marrow of atopic subjects. J Allergy Clin Immunol, 2002, 110:96-101.
  • 3Murray J, Ward c, O′ Flaberty JT, et al. Role of leukotrenes in the regulation of human granulecyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis. Br J Pharmacol, 2003, 139:388-398.
  • 4Henderson WR Jr, Tang LO, Chu SJ, et al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med, 2002, 165:108-116.
  • 5Stelmach I, Jerzynska J, Kuna P. A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum ECP, sIL-2R, IL-4, and sICAM-1 in children with asthma. J Allergy Clin Immunol, 2002,109: 257-263.
  • 6Stelmach I, Grzelewski T, Stelmach W, et al. Effect of triamcinolone acetonide, montelukast, nedocromil sodium and formoterol on eosinophil blood counts, ECP serum levels and clinical progression of asthma in children. Pol Merkuriusz Lek, 2002,12:208-213.
  • 7Strauch E, Moske O, Thoma S, et al. A randomized controlled trial on the effect of montelukast on sputum eosinophil cationic protein in children with corticosteroid-dependent asthma. Pediatr Res, 2003, 54:198-203.
  • 8Diamant Z, Grootendorst DC, Veselic-Charvat M, et al. The effect of montelukast (MK-0476), a cysteinyl leukotriene receptor antagonist, on allergen-induced airway responses and sputum cell counts in asthma. Clin Exp Allergy, 1999, 29:42-51.
  • 9Wu AY, Chik SC, Chan AW, et al. Anti-inflammatory effects of high-dose montelukast in an animal model of acute asthma. Clin Exp Allergy, 2003, 33:359-366.
  • 10Finsnes F, Lyberg T, Christensen G, et al. Leukotriene antagonism reduces the generation of endothelin-1 and IFN-γand inhibits eosinophilic airway inflammation. Respir Med, 2002,96: 901-906.

共引文献404

同被引文献198

引证文献7

二级引证文献76

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部