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p15基因的研究进展 被引量:5

Research Progress in p15 Gene
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摘要 p15基因是定位于染色体9p21区域的肿瘤抑制基因,属于p15/p20家族,通过抑制细胞周期素依赖激酶4/6(CDK4/6)阻止细胞由G1期进入S期,从而减少细胞的异常生长及变异,阻止肿瘤发生和发展。当p15基因发生改变,则可能导致肿瘤发生和进展。p15基因异常还与其它疾病,如浆细胞疾病、某些癌前病变等发生有一定的关系。
作者 陈恩 肖建华
出处 《肿瘤学杂志》 CAS 2009年第3期246-247,共2页 Journal of Chinese Oncology
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参考文献16

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