儿童桥本甲状腺炎IL-10和IL-12及相关指标变化的临床价值

Clinical value of serum IL-10,IL-12 and relative index level changed in children with Hashimoto thyroiditis

目的:观察儿童桥本甲状腺炎(HT)患者血清IL-10和IL-12水平的变化,进一步探讨HT临床识别和预测的炎症指标。方法:采用ELISA测定儿童HT患者在疾病不同阶段(分为新发病,治疗未缓解,治疗缓解3个阶段)血清IL-10和IL-12浓度,分析其与甲状腺功能(FT3、FT4、sTSH)、甲状腺自身抗体(TGAb、TMAb、TRAb、TSI)等指标之间的关系。结果:(1)HT各组IL-10均显著低于对照组(P<0.01),IL-12均显著高于对照组(P<0.01)。(2)HT组IL-10与FT4、FT3呈显著正相关(均P<0.001),与sTSH呈显著负相关(P<0.05)。(3)IL-12与FT4、FT3呈显著负相关(均P<0.001);与sTSH水平呈正相关(P<0.001)。结论:IL-12与HT的发病密切相关,IL-10在该病中则具有一定的保护作用,二者均可作为病情监测的指标。

Objective： To observe the change of IL-10 and IL-12 in serum of children with Hashimoto thyroiditis（HT） and explore inflammatory index for clinical identification and forecast of HT. Methods： The serum IL-10 and IL-12 concentrations of patients with HT in different stages respectively （the patients preliminary diagnosed, the patients unrelieved and the patients relieved） were measured by ELISA . The correlativity of IL-10,IL-12 and other parameters were analyzed. Results： （1）IL-10 level was significantly lower in patients with HT than that of control group（P〈0.01 ）.IL-12 level was significantly higher in patient with HT than that of control group（P〈0.01 ）.（2）IL-10 level in patients with HT was positively correlated with FT3 and FT4（all P〈0.001 ）, and was negatively correlated with sTSH （P〈0.05）.（3）IL-12 level in patients with HT was negatively correlated with FT3 and FT4（all P〈0.001 ）, and was positively correlated with sTSH （P〈0.001）. Conclusion： IL-12 has effect on HT, while IL-10 has certain protective effect on this disease. Both of them can be the signs of disease monitoring.