茶多酚免疫药理作用研究

Study of the immunopharmacological effects of tea polyphenols

目的:研究茶提取物—茶多酚(TP)对小鼠淋巴细胞免疫功能的影响。方法:采用MTT法测定TP在离体给药时对ConA诱导小鼠脾淋巴细胞及小鼠巨噬细胞增殖反应的影响。结果:体外实验证明,TP对丝裂原诱导的小鼠脾淋巴细胞和小鼠巨噬细胞增殖反应具有明显的增强作用,可以显著增强ConA诱导的小鼠离体脾淋巴细胞及小鼠离体巨噬细胞增殖反应。结论:TP具有免疫增强作用。

Objective： To observe the effects of the extract of green tea-tea polyphenols （TP）on the immune functions.Methods： The mice spleen lymphocyte proliferation and mouse macrophage proliferation induced by mitogens ConA in vitro was adopted by MTT method. Results： TP could obviously enhance the proliferation of mouse spleen lymphocyte and mouse macrophage induced by ConA at concentration within 10 μg/ml to 600μg/ml in vitro.Conclusion： TP can significantly improve the effectiveness of immunization.