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谷氨酸能系统在阿片耐受脊髓可塑性改变中的作用 被引量：2

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摘要 阿片一直以来被广泛用于临床疼痛治疗。但其长时间应用可矛盾性地引起痛觉过敏。发生耐受现象（opioid tolerance），增加剂量以克服疼痛和耐受的结果是造成更大的耐受和更严重的痛觉过敏．从而形成恶性循环，大大限制了阿片类药物的临床应用。阿片耐受的机制复杂，有许多调节因素参与其中。对阿片耐受经典假说的解释为阿片受体信号通路的脱敏和细胞表面功能性受体的缺失，
作者 陈怡 王国林
机构地区 天津医科大学总医院麻醉科
出处 《天津医科大学学报》 2009年第1期155-157,161,共4页 Journal of Tianjin Medical University
基金 天津市自然科学基金资助项目(06YFJMJC08600) 天津市卫生局基金资助项目(06KZ51)
关键词 谷氨酸 阿片耐受 脊髓 神经可塑性 NMDA受体 谷氨酸转运体
分类号 R614.1 [医药卫生—麻醉学]
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参考文献27

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同被引文献49

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天津医科大学学报
2009年 第1期

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