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宫颈癌相关基因甲基化研究 被引量：3

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摘要 DNA甲基化属于表观遗传修饰的一种，是真核细胞DNA最普遍的修饰方式，可以通过影响基因突变、表达调控、细胞增殖等调节基因转录活性和表达。研究发现基因启动子甲基化的程度直接影响基因的转录活性，并且呈负相关。由于肿瘤的形成从本质上讲就是细胞原癌基因的激活和抑癌基因的失活所致，所以异常的DNA甲基化在致癌作用上扮演了重要角色。
作者 唐世倩 吴素慧
机构地区 山西医科大学第一临床医学院
出处 《临床医药实践》 2009年第3期163-165,共3页 Proceeding of Clinical Medicine
关键词 基因甲基化 宫颈癌 基因启动子甲基化 表观遗传修饰 DNA甲基化 基因转录活性 真核细胞DNA 细胞原癌基因
分类号 R734.2 [医药卫生—肿瘤] R737.33 [医药卫生—肿瘤]
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参考文献11

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同被引文献48

  • 1Berger SL. The complex language of chromatin regulation during transcription [J]. Nature, 2007, 447(7143): 407-412.
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  • 9Zhang Z, Job K, Yatsuki H, et al. Rctinoic acid receptor beta7, is epigenetically silenced either by DNA methylation or repressive histane modifications at the promoter in cervical cancer cells [J]. Cancer Lett, 2007, 247(2): 318-327.
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临床医药实践
2009年 第3期

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