1086例非淋菌性尿道炎患者支原体感染情况及药敏结果分析

Infection status and drug susceptibility analysis of mycoplasma strains in 1086 patients with nongonococcal urethritis

目的：通过分析2007年1月-2008年10月间非淋球菌性尿道炎患者支原体感染及耐药性变迁情况，为临床提供最新的流行病学资料及合理用药的科学依据。方法：应用法国Bio—Merieux生产的IST2试剂盒进行支原体培养及药敏试验，并统计分析结果。结果：本组1086例疑似非淋菌性尿道炎（NGU）患者中447例支原体培养阳性，阳性率为41．16％，其中解脲脲支原体（Uu）占85．9％；人支原体（Mh）占0．67％；Uu＋Mh占13．42％。女性支原体发病率较男性高。药敏结果表明：支原体对9种抗菌药物耐药率最高的是环丙沙星（86．35％）、氧氟沙星（67．79％）、红霉素（30．65％），敏感率最高的药物为强力霉素（98．43％），原始霉素（98．21％）交沙霉素（91．05％）。男女感染Uu＋Mh的敏感药物基本相同。结论：非淋菌性尿道炎支原体感染主要以Uu发病率最高，且在太原地区女性检出率高于男性，在临床中对支原体感染治疗应根据药敏结果合理使用抗生素，以减少耐药菌株产生，目前在太原地区可首选强力霉素进行治疗。

Objective：To investigate the infection status and drug resistance of mycoplasma strains isolated from nongonococcal urethritis. Methods ：The IST2 kit produced by Bio merieux was used to culture the mycoplasma strains and to do drug susceptibility test. Rusults ..The positive is 447 and the Mycoplasma infection ratio was 41.16% ,with ureaplasmaureal yticum（Uu）85.9% ,mycoplasma hominis（Mh）0.67%and mixed infection 13.42%. The drug susceptibility test showed that drug resistance ratios were as follows ：to ciprofloxacin（86.35%）,ofloxacin （67.79%）,erythromycin（30. 65%） ,drug susceptibility ratios were as follows ：to deoxyeycline （98. 43% ） ,pristinamycin（98.21% ）and josamycin （91.05 % ）. Conclusion：Mycoplasma infection in genitourinary tract is mainly due to Uu infection. And the female is prone to infect the Uu. We should rationally choose and use antibiotics according to the drug susceptibility to avoidance the product of the resistance strains ,and deoxycycline is very effective in the Taiyuan region.