化学疗法与核素治疗多发骨转移癌疗效对比

Treatment Efficacy of Chemotherapy vs Radionuclide Therapy in Multiple Bone Metastasis

目的:观察化学疗法及核素治疗骨转移癌的疗效。方法:对骨转移癌患者分别予以化学疗法及核素治疗,观察不同方法的疗效。结果:化学疗法治疗组中骨痛的缓解率分别是完全缓解(CR)0%,部分缓解(PR)8.3%;骨显像的变化是CR0%,PR7.7%,稳定0%;而核素治疗骨转移癌的疗效明确,骨痛的缓解率达到70.3%,骨显像异常浓聚点虽然CR为0%,但PR为45.9%,稳定为43.3%。结论:核素治疗骨转移疗效明确,其中153Sm?EDTMP疗效更优于89SrCl2。

Objective： To observe the treatment efficacy of chemotherapy vs radionuclide therapy in multiple bone metastasis. Methods： A cohort of patients with multiple bone metastasis were randomized to receive chemotherapy or radionuclide therapy. Treatment efficacy of these two modalities were compared between the groups. Results： Chemotherapy resulted in relief of osteodynia with 0% by complete remission（CR） and 8.3% by partial remission（PR）, and improvement of bone imaging with 0% by CR, 7.7% by PR and 0% by stability （ST）. On the other hand, radionuclide therapy significantly resulted in 70.3% relief of osteodynia. While the improvement of abnormal nuclide accumulations in bone images was 0% by CR, the PR was 45.9% and ST was 43.3%. Conclusion： Radionuclide therapy appeared to provide more demonstrated efficacy for treatment of multiple bone metastasis. ^153Sm-EDTMP resulted in more favorable outcomes as compared with ^89SrCl2.