维甲酸加化疗和小剂量肝素治疗急性早幼粒细胞白血病15例临床观察

Retinoic Acid,Chemotherapy and Low Dose Heparin in Treatment of Acute Promyelocytic Leukemia:Clinical Observation of 15 Cases

目的总结维甲酸、化疗、小剂量肝素合用治疗急性早幼粒细胞白血病(APL)并预防弥漫性血管内凝血(D IC)的疗效。方法15例APL患者,采用全反式维甲酸(ATRA)、适量化疗诱导分化至完全缓解(CR),同时予以小剂量肝素。结果APL的完全缓解率达86.7%,平均缓解时间达37.4 d,无一例D IC发生。结论维甲酸、化疗、小剂量肝素合用治疗急性早幼粒细胞白血病并预防D IC效果满意。

[ Objective] To summarize the effect of retinoic acid, chemotherapy and low dose heparin for treating acute promyelocytic leukemia （APL） and preventing diffuse intravascular coagulation （ DIC ）. [ Methods] 15 APL patients received differentiation therapy with all-trans retinoic acid （ ATRA ）combined with proper chemo and low dose heparin until complete remission （ CR ）was obtained. [ Results] CR was attained in 86.7% of the APL patients, and the average time of attaining CR of 37. 4 days. There was no complication of DIC during the treatment course. [ Conclusion] A regimen of ATRA, chemo and low dose heparin has satisfactory effects for treating APL as well as preventing DIC.