2型糖尿病患者无症状性颅内动脉狭窄的相关性研究

CLINICAL STUDY ON CORRELATIONS OF INTRACRANIAL ARTERIOSTENOSIS WITH TYPE 2 DIABETES MELLITUS

目的观察2型糖尿病患者无症状性颅内动脉狭窄的经颅多普勒(TCD)特点及其危险因素。方法收集135例体检2型糖尿病患者,排除合并中风、高血压及其他颅内疾病。用TCD检查颅内动脉狭窄情况,观察年龄和血尿酸水平对颅内动脉狭窄的影响。结果135例患者中有39例有颅内动脉狭窄,患病率为28.89%。检查动脉1 115条,狭窄动脉57条,总的动脉狭窄率为5.11%。其中大脑中动脉(MCA)狭窄率最高,大脑后动脉未出现狭窄。颈内动脉系统的动脉狭窄率显著高于椎基底动脉系统。老年组患者总的颅内动脉狭窄率及单一动脉狭窄率均高于非老年组患者。狭窄组血尿酸水平明显高于非狭窄组。结论2型糖尿病患者颅内动脉狭窄最常发生于大脑中动脉,年龄和血尿酸水平升高是2型糖尿病患者无症状性颅内动脉狭窄的危险因素。

Objective To study the risk factors of asymptomatic intracranial arteriostenosis in patients with type 2 diabetes mellitus（DM） by doppler observation. Methods Patients（135 cases） with type 2 DM were recruited. Exclusive criteria was： stroke, other intracranial diseases and hypertension. Intracranial arteriostenosis was evaluated using transcranial doppler sonography （TCD）. Results The prevalence rate of patients with asymptomatic intracranial arteriostenosis was 28.89 % （39/135）. Among 1 115 arteries checked,57 stenosis arteries were with arteriostenosis（5.11% ）. The stenosis in internal arterial system was more common than that in vertebrobasilar arterial system. The most common site of stenosis was in middle cerebral artery （MCA）. The total rate of stenotic artery in elder type 2 DM patients was higher than that in non-elder. The patients with arteriostenosis had significantly higher uric acid than those without stensis. Conclusion The most common site of asymptomatic intracranial arteriostenosis is MCA. Age and uric acid are associated with asymptomatic intracranial arteriostenosis in patients with type 2 DM.