连云港市2008年221例预防接种不良反应分析

Analysis of Adverse Events Following Immunization in Lianyungang city in 2008

目的分析连云港市预防接种不良反应发生特点,为今后工作中进一步降低预防接种不良反应的发生提供科学依据。方法对221例预防接种不良反应通过网络直报上报和月报告一览报表上报的相关信息进行流行病学统计分析和数据汇总。结果共有17种生物制品发生221例不良反应,总发生率为25.18/10万,发生年龄主要集中在0岁～组和1岁～组,两年龄组发生数占总发生数的80.54%。发生的不良反应以一般反应为主共206例,占总数的93.21%。临床诊断以局部红肿浸润为最多,占总数的54.30%。结论疫苗不良反应的发生与多种因素有关,多种疫苗均可发生,但发生率并不相同,提高基层接种人员的业务素质,严格掌握疫苗接种禁忌证,可以有效减少预防接种不良反应的发生。

[ Objective] To analyze the features of adverse events following immunization （ AFEI ） in Lianyungang city in 2008, and provide scientific evidence for reducing the incidence of AFEI. [ Methods] The 221 AFEL cases were collected and reported by the Direct Network Report and monthly report list. The related information was analyzed by epidemical statistics. [ Results ] A total of 221 AFEL cases induced by 17 kinds of biological products were reported, the total incidence was 25.18/ 100 000, most cases （ 80.54%） concentrated on 2 age groups of 0 year and 1 year. 206 cases （ 93.21% ） of AEFI were general adverse events. 54.30% are clinically diagnosed as local flare and infiltration. [ Conclusion] AFEI occurs with a variety of factors, Multiple vaccines may involve, but the incidences are not the same. Improving professional quality of grass-roots vaccinators and strictly mastering vaccination contraindications can reduce tile AEFI effectively.