亚硝化农肥水中N-亚硝基化合物的分析

The analysis on types of N-nitroso compounds in the farm compost polluted water with nitrosation

目的分析亚硝化农肥水中N-亚硝基化合物的种类。方法使用特异的高效液相色谱—光水解、热裂解—热能分析仪联机技术(HPLC-PHPS-TEA)进行分析检测。结果在亚硝化农肥水中发现N-亚硝基甲基脲(MNU),二甲基亚硝胺(NDMA);结论农肥水中含N-亚硝基化合物的胺类、酰胺类前体物:二甲胺和甲基脲。亚硝化农肥水中含有N-亚硝基化合物:二甲基亚硝胺和N-亚硝基甲基脲。这是两种能引起动物胃癌、食管癌和肝癌的N-亚硝基化合物。因此,从环境微生物、环境化学角度为"食管癌、胃癌和肝癌的氮循环——N-亚硝基化合物前体物病因假说"提供了有力的佐证。另外,使用我们的专利《消除饮用水中N-亚硝基化合物及其前体物的方法》作为干预措施,经过干预处理的农肥水,不管是否亚硝化,均无N-亚硝基化合物。证明专利方法有效,可以直接应用于食管癌、胃癌和肝癌的病因预防。

Objective To analyze the types of N-nitroso compound in the farm compost polluted water with nitrosation.Method（HPLC-PHPS-TEA） was used to detect the N-nitroso compound in the farm compost polluted water with nitrosation.Result N-methy1-N-nitrosourea（MNU） and dimethyl-nitrosamin（NDMA） were detected.Conclusion The precursors of N-nitroso compound,dimethyl-amin and N-methy1-urea were two components of the farm compost polluted water.The N-nitroso compound including MNU and NDMA were detected in the farm compost polluted water with nitrosation.No matter nitrosation or not,not any N-nitroso compound was detected in the farm compost polluted water.The result provides the verification of etiological hypothesis of nitrogen cycle.