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以PHBV-PLGA为载体的硫酸庆大霉素缓释微球 被引量：1

Poly(Hydroxybutyrate-Hydroxyvalerate)-Poly(Lactide-co-Glycolide) Sustained-Release Microspheres Entrapping Gentamicin Sulfate
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摘要 以生物可降解聚羟基丁酸酯和羟基戊酸酯的共聚物（PHBV）、乙交酯和丙交酯的无规共聚物（PLGA）两种高分子作为壁材，采用复乳溶剂挥发法，制备了包裹硫酸庆大霉素（GS）的载药微球。在扫描电镜下观察到所得微球表面呈多孔状，为球形或椭圆形，粒径在20-80μm。分析结果表明，包封率在60％以上，在体外16-20d内药物全部释放，90d微球体外降解50％左右。 Biodegradable poly （ hydroxybutyrate-hydroxyvalerate）-poly （lactide-co-glycolide） （ PHBV- PLGA） microspheres with gentamicin-loading were prepared and characterized by solid-oil-oil-water method. The diameter of the microspheres with spherical or ellipsoidal shape ranges in 20- 80 /zm and the encapsulation efficiency of gentamicin sulfate is more than 60~//00. The cumulative rate of drug-release reaches 100~ in 16--20 d. In addition, the degradation properties are investigated. The cumulative drug release is about 50% in 90 d in phosphate buffer solution.
作者 谭红香 叶建东 柯渔
机构地区 华南理工大学材料学院特种功能材料教育部重点实验室
出处 《功能高分子学报》 CAS CSCD 北大核心 2009年第1期12-16,共5页 Journal of Functional Polymers
基金 广东省自然科学基金项目(04205786) 国家科技支撑计划项目(2006BAI16B03)
关键词 PHBV PLGA 硫酸庆大霉素 药物缓释微球 PHBV PLGA gentamicin sulfate drug release microsphere
分类号 R63 [医药卫生—外科学]
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参考文献11

  • 1Naraharisetti P K, Guan Lee H C, Fu Y C, et al. in vitro and in vivo release of gentamicin from biodegradable discs[J]. Biomed Mater Res B Appl Biomater, 2006, 77(2) : 329-337.
  • 2Joosten U, Joist A, Gosheger G, et al. Effectiveness of hydroxyapatite-vancomycin bone cement in the treatment of staphylococcus aureus induced chronic osteomyelitis[J]. Biomaterials, 2005, 26(25): 5251-5258.
  • 3Changez M, Koul V, Dinda A K. Efficacy oI antibiotics-loaded interpenetrating network (IPNs) hydrogel based on poly(acrylic acid) and gelatin for treatment of experimental osteomyelitis: in vivo study[J]. Biomaterials, 2005, 26(14) : 2095-2104.
  • 4Virto M R, Elorza B, Torrado S, et al. Improvement of gentamicin poly(D,L-lactic-co-glycolic acid) microspheres for treatment of osteomyelitis induced by orthopedic procedures[J].Biomaterials, 2007, 28(5) : 877-885.
  • 5Baro M, Sanchez E, Delgado A, et al. in vitro-in vivo characterization of gentamicin bone implants[J]. J Control Release, 2002, 83 (3): 353-364.
  • 6Li Haiyan, Chang Jiang. Preparation characterization and in vitro release of gentamicin from PHBV/wollastonite composite microspheres[J].J Control Release, 2005, 107(3):463-473.
  • 7Leach K J, Takahashi S, Mathiowitz E. Degradation of double walled polymer microspheres of PLLA and P(CPP : SA) 20: 80: II. in vivo degradation[J]. Biomaterials, 1998, 19(21):1981-1988.
  • 8Prior S, Gamazo C, Irache J M, et al. Gentamicin encapsulation in PLA/PLGA microspheres in view of treating brucella infections[J]. International Journal of Pharmaceutics, 2000, 196(1): 115-125.
  • 9Sivakumar M, Panduranga Rao K. Preparation, characterization and in vitro release of gentamicin from coralline hydroxyapatite-gelatin composite microspheres[J]. Biomaterials, 2002, 23(15): 3175-3181.
  • 10Zhang X C, Wyss U P, Pichora D, et al. Biodegradable controlled antibiotic release devices for osteomyelitis:Optimization of release properties[J]. J Pharm Pharmacol, 1994, 46(9): 718-724.

同被引文献18

  • 1Misra R, Sahoo S K. Antibacterial activity of doxycycline-loaded nanoparticles[J]. Methods Enzymol, 2012, 509: 61-85.
  • 2Wang S N, Wang X Y, Xu H, et al. Towards sustained delivery of small molecular drugs using hydroxyapatite microspheres as the vehicle[J]. Adv Powder Technol, 2010, 21(3): 268-272.
  • 3Wang X Y, Xua H, Zhao Y Q, et al. Poly (lactide-co-glycolide) encapsulated hydroxyapatite microspheres for sustained release of doxycycline[J]. Mater Sci Eng B, 2012, 177(4): 367-372.
  • 4Qi R L, Guo R, Zheng F Y, et al. Controlled release & antibacteria activity of antibiotic-loadedelectrospun halloy-site/poly(lactic-co glycolic acid) compositenanofibers[J]. Coil SutJ'B Biointerf, 2013, 110(1):148-155.
  • 5Wang F, Ni B, Zhu Z, et al. Intra-discal vancomycin-loaded PLGA microsphere injection for MRSA discitis: an experimental study[J]. Arch Orthop Trauma Surg, 2011, 131 ( I ): I 11 - I 19.
  • 6Han B, Wang H T, Liu H Y, et al. Preparation of pingyangmycin PLGA microspheres and related in vitroin vivo studies[J], lnt J Pharm, 2010 398(I/2): 130-136.
  • 7Wang C, Liu J, Pan W, et al. Pingyangmycin loaded bovine serum albumin microspheres tbr chemoembolization therapy--in vitro and vivo studies[J]. Int J Pharm, 2008, 351 ( 1/2): 219-226.
  • 8lmbuluzqueta E, Gamazo C, Lana H, et al. Hydrophobic gentamicin- oaded nanoparticles are effective against Brucella melitensis infection n mice[J]. Antimicrob Agents Chemother, 2013, 57(7): 3326-3333.
  • 9Balmayora E R, Barana E T, Azevedo H S, et al. Injectable biodegradable starch/chitosan delivery system for the sustained release of gentamicin to treat bone infections[J]. Carbohydr Polym, 2012, 87(1 ): 32-39.
  • 10Valarezo E, Tammaro L, Gonzfilez S, et al. Fabrication and sustained release properties of poly(e-caprolactone) electrospun fibers loaded with layered double hydroxide nanoparticles intercalated with amoxicillin[J] Appl CTa), Sci, 2013, 72(2): 104-109.

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功能高分子学报
2009年 第1期

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