苦参素注射液联合双途径化疗治疗中晚期腹腔肿瘤临床观察

Cinical study of matrine combined two-way chemotherapy on advanced abdominal neoplasms

目的:探讨苦参素注射液与静脉及腹腔双途径化疗联合应用对中晚期腹腔恶性肿瘤的疗效。方法:将72例中晚期腹腔恶性肿瘤患者随机分为治疗组(静脉及腹腔双途径化疗+苦参素注射液)和对照组(静脉及腹腔双途径化疗),观察两组腹水控制疗效、不良反应、免疫功能状况、生活质量。结果:两组体重、卡洛夫斯基行为表现评分(KPS)、T淋巴细胞亚群相比差异有显著性,恶心、呕吐及骨髓抑制等不良反应亦差异有显著性。结论:苦参素注射液联合静脉及腹腔双途径化疗能增强晚期腹腔肿瘤患者免疫功能,改善生活质量,减少恶心、呕吐及骨髓抑制等不良反应。

Objective：To study matrine combined two-way chemotherapy on advanced abdominal neoplasms. Methods：72 cases of advanced abdominal neoplasms were divided randomly into two groups, 36 cases in observation group received the treatment of matrine combined two-way chemotherapy,and 36 cases in control group received two-way chemotherapy alone. The therapeutic efficacy on ascitics,side effects,immunity condition and life quality were evaluated. Results：The two groups were significantly different in weight change, Kamofsky score,T lymphocyte subsets. There was significantly different in occurrence of nausea, vomit and bone marrow suppres- sion in the two groups.Conclusion ：The treatment of matrine combined two-way chemotheraphy could improve immunity condition and life quality of patients, reduce occurrence of nausea, vomit and bone marrow suppression toxicity.