387例药品不良事件报告分析

Adverse drug events:analysis of 387 cases

目的:观察药品不良事件(ADE)的发生情况及影响因素。方法:收集2008年1～11月我市上报的387例药品不良反应(ADR),并作统计分析。结果:387例药品ADE中,涉及品种最多的为抗感染类药物(41.13%),发生ADE的主要途径为静脉给药(79.07%);ADE最常累及皮肤及其附件(51.16%);140例(36.18%)不按说明书用药,其中84例涉及抗感染药。结论:医务工作者应加强药物知识学习,注意药物使用各环节的安全。

Objective：To investigate the incidence,clinical features and influential factors of adverse drug events appeared in Baoshan area. Methods：387 cases with adverse drug events reporte.d in our hospital from Jan. to Nov.in 2008 were analyzed statistically. Results：Of the total drugs inducing adverse drug events（387cases）, anti- infectives took the lead（41.13%）,which was related to its great variety,high application frequency and application range;79.07% were induced by intravenous infusion,51.16% were manifested as lesion of skin and its appendants; 140（36.18%） failed to follow the direction of package inserts,of which,84 cases involved the use of anti- infectives. Conclusion： Medical workers should attach great importance to the acquisition of medication knowledge as well as the medication safety at each steps.