2型糖尿病患者口服降糖药的成本效果分析

Cost-effectiveness analysis of drugs in treatment of type 2 diabetes mellitus

目的:分析比较7种治疗2型糖尿病(DM)药物的成本效果。方法:将705例2型DM患者分成7组,运用药物经济学成本效果分析(CEA)方法,对7组口服降糖药[A组:马来酸罗格列酮(文迪雅);B组:盐酸二甲双胍;C组:格列齐特(达美康);D组:格列美脲;E组:格列喹酮(糖适平);F组:阿卡波糖(拜糖平);G组:阿卡波糖(卡博平)]进行评价;并同时做敏感度分析。结果:在2型DM的治疗中,二甲双胍为疗效较好且最经济的方案。结论:二甲双胍治疗2型DM安全性最佳、疗效最好、费用最合理,值得临床推广应用。

Objective ：To compare and analyze the cost-effectiveness of 7 different drugs in the treatment of type 2 diabetes mellitus （DM）. Methods： 705 cases with type 2 DM were divided into 7 groups. The cost-effectiveness analysis,seven kinds of oral hypoglycemic drugs（group A：rosigltazone maleate ;group B ： meltformin; group C ： gliclazide ; group D ： ghmepiride ; group E ： gliquidone ; group F ： glucobay ; group G：kaboping） were performed and compared,at the same time,sensitive analysis was performed. Results： During the treatment of type 2 diabetes mellitus, mefformin was the most economical drug and had better therapeutic effect. Conclusion：The best drugs for type 2 diabetes mellitus should be the one with safety, most efficiency and lower price.