期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

心源性恶液质的机制研究进展 被引量：1

下载PDF
导出
摘要 恶液质是慢性疾病的晚期表现，以消瘦为特征。慢性充血性心力衰竭（Chronic heart failure，CHF）时患者会出现不同程度的机体消耗．随着脂肪组织、瘦体质和骨组织减少到一定程度就出现了心源性恶液质（syndrome of cardiac cachexia，SOCC）。SOCC的出现往往提示预后不良，是独立于年龄、左室射血分数、运动耐量之外的一项重要的预后因素。越来越多的证据表明免疫和神经内分泌异常在SOCC发生发展过程中起着关键的作用。
作者 叶小帆 徐晨光
机构地区 中山大学附属第一医院心脏外科
出处 《现代医药卫生》 2009年第8期1177-1179,共3页 Journal of Modern Medicine & Health
关键词 心源性恶液质 慢性充血性心力衰竭 神经内分泌异常 左室射血分数 SOCC 慢性疾病 脂肪组织 预后不良
分类号 R541 [医药卫生—心血管疾病] R541.61 [医药卫生—心血管疾病]
  • 相关文献

参考文献13

  • 1Anker SD, Coats AJS.Cardiac cachexia :a syndrome with impaired survival and immune and neuroendocrine aetivation[J].Chest, 1999, 115:836.
  • 2King D, Smith ML,Chapman TJ ,et al.Fat malabsorption in elderly patients with cardiac cachexia[J].Age Ageing, 1996,25 : 144.
  • 3Anker SD ,Chua TP,Ponikowski P,et al.Hormonal changes and eatabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia[J].Circulation, 1997,96:526.
  • 4Harrington D,Anker SD ,Chua TP,et al.Skeletal muscle function and its relation to exercise tolerance in chronic heart failure[J].Am Coil Cardiol, 1997,30:1758.
  • 5Vescovo G,Serafini F,Facchin L,et al.Specific changes in skeletal muscle myosin heavychains composition in cardiac failure:differences compared with disuse atrophy as assessed on nficrobiopsies by high resolution electrophoresis[J].Heart, 1996,76 : 337.
  • 6Berry C ,Clark AL.Catabolism in chronic heart failure[J].Eur Heart J, 2000,21:521.
  • 7Yoshizumi M ,Perrella MA.Bumett JC .et al.Tumor necrosis factordownregulates an endothelial nitric oxide synthase mRNA by shortening its half-life[J].Circ Res, 1993,73:205.
  • 8Levine B,Kalman J ,Mayer L,et al.Elevated circulating levels of tumor necrosis factor in severe chronic heart failure[J].N Engl J Med, 1990,323:236.
  • 9Barton BE.IL-6:insights into novel biological activities[J]. Clin lmmunol Immunopathol, 1997,85 : 16.
  • 10Langhans W. Hnlpka B.Interleukins and tumor necrosis factor as inhibitors of food intake[J].Neuropeptides, 1999,33:415.

同被引文献21

  • 1秦薇,蔡久英.GH/IGF-1治疗心力衰竭作用机制的研究进展[J].心血管病学进展,2005,26(6):578-581. 被引量：3
  • 2Trobec K,von Haehling S, Anker SD,找 al. Growth hormone,insu-lin-like growth factor 1,and insulin signaling-a pharmacologicaltarget in body wasting and cachexia [J]. Cachexia SarcopeniaMuscle,2011,2(4) :191-200.
  • 3Muscaritoli M,Anker SD, Argil6s Jyet al. Consensus definition ofsarcopenia,cachexia and precachexia:joint document elaborated bySpecial Interest Groups (SIG) 11 cachexia-anorexia in chronic wast-ing diseases" and " nutrition in geriatrics" [J]. Clin Nutr,2010,29(2):154-159.
  • 4Palus S,Schur R,Akashi YJ,et al. Ghrelin and its analogues,BIM-28131 and BIM-28125, improve body weight and regulate theexpression of MuRF-1 and maft>x in a ratheart failure model [J].PLoS One,2011,6(11) :l-2.
  • 5Ottosson M,Lonnroth P, Bjomtorp P,et al. Effects of cortisol andgrowth hormone on lipolysis in human adipose tissue [J] . J ClinEndocrinol Metas, 2000,85 (2) ; 799-803.
  • 6Previs SF,Withers DJ,Ren JM,et al. Contrasting effects of IRS-1versus IRS-2 gene disruption on carbohydrate and lipid metabolismin vivo[J]. J Biol Chem,2000,275(50) :38990-38994.
  • 7Kido Y, Nakae J, Accili D. The insulin receptor and its celluartargets[J]. J Clin Endocr Metab,2001,86(3) :972-979.
  • 8Laurizen HP, Galbo H, Toyoda T, et al. Kinetics of contraction-induced GLUT4 translocation in skeletal muscle fibers from livingmice[J]. Diabetes,2010,59(9) :2133-2144.
  • 9Chang L,Chiang SH,Saltiel AR. Insulin signaling and the regula-tion of glucose transport[J]. Mol Med,2004,10(7/12) :65-71.
  • 10Nielsen C,Gormsen LC,Jessen N,ei al. Growth hormone signalingin vivo human muscle and adipose tissue : impact of insulin,sub-strate background, and growth hormone receptor blockade [J]. JClin Endocrin Metab,2008,93(7) :2842-2850.

二级引证文献3

现代医药卫生
2009年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部