子宫内膜癌中CD_(105)的表达及意义

The expression and significance of CD_(105) in endometrial carcinoma

目的通过与CD34比较,研究CD105与子宫内膜癌发生、发展及预后的关系。方法采用免疫组化法检测子宫内膜癌25例(子宫内膜癌组)、非典型增生13例(非典型增生组)、正常内膜8例(对照组)中CD105、CD34、VEGF、ki-67的表达,CD105-MVD与临床参数进行分析。结果子宫内膜癌组和非典型增生组的表达显著高于对照组(P<0.05),非典型增生组与子宫内膜癌组间差异无统计学意义(P>0.05);CD105-MVD与FIGO手术-病理分期、浸润肌层深度及局部淋巴结转移呈显著正相关(P<0.01)。结论CD105优于CD34,可用来预测非典型增生的恶变倾向,反映子宫内膜癌增殖生长状态,并可提供更多的预后信息。

Objective To investigate the relationship between CD105 and the pathogenesis, development and prognosis of endometrial tumor, as compared with CD34. Methods The expression of CD105, CD34, VEGF and ki-67 was detected by immtmohistochemistry in 25 cases of endomet6al carcinoma（EC）, 13 cases of atypical hyperplasia （AH） and 8 cases of normal endometria. The relationship between MVD-CD105 and clinical parameters was analyzed. ReSults CD105-MVD of the EC group and AH group was significantly higher than that of control group（ P 〈 0.05）, however, there was no significant difference between EC group and AH group（ P 〉 0.05）. CD105-MVD was closely correlated with the FIGO stage, depth of infiltrating muscular layer and regional nodal metastasis（ P 〈 0. 05）. Conclusion CD105 is superior to CD34 in predicting the cancerous tendency of AH, reflecting the proliferating status of endometrial cancer and providing more prognostic information.