肾素-血管紧张素系统基因多态性与冠心病预后的关系

Relationship of RAS gene polymorphisms and major adverse cardiac events after percutaneous coronary intervention

目的探讨血管紧张素转换酶(ACE)和血管紧张素原(AGT)基因多态性对随访的佛山地区汉族人冠心病冠脉介入术后心血管事件的影响。方法研究选取133例冠心病冠脉介入术后患者,随访期间发生心血管事件组与无心血管事件组进行比较,并使用基因芯片技术测定其ACE和AGT基因多态性。结果随访36～48个月,联合终点:心力衰竭、心肌梗死、心源性猝死或再血管化有38例,心血管事件组AGT基因多态性比无心血管事件组显著增加(P<0.05),ACE基因I/D多态性在两组中的分布无统计学意义。结论中长期随访,AGT基因M235T多态性与中国南方部分汉族人群冠心病患者发生心血管事件有关,AGT基因M235T基因可能是该地区冠心病冠脉介入术后心血管事件发病的遗传危险因素。

Objective To investigate the influence of ACE and AGT gene polymorphisms on follow-up events in a population of chinese adults with coronary artery disease after percutaneous coronary intervention. Methods The study population consisted of 133 patients with coronary artery disease after percutaneous coronary intervention. Patients with events during followup were compared with those patients without events. Angiotensin I converting enzyme and angiotensinogen gene polymorphisms were tested whth gene chip technology. Results During follow-up （36 -48 months） the overall combined end points （myocardial insufficiency, cardiac death, myocardial infarction, and revascularizaton procedures） accounted for 38 events. AGT gene polymorphism was significantly more prevalent in the group of patients with events. No significant difference was observed in ACE genotype distribution between the two groups. Conclusion Short-and medium-term follow-up, AGT gene polymorphism was related to follow-up events in a population of chinese adults with coronary artery disease after percutaneous coronary intervention, AGT M235T but not ACE gene polymorphism appeared to be a risk factor of adverse events after percutaneous coronary intervention.