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大鼠肾上腺IL-10的表达

Expression of interleukin-10 in normal rat adrenal gland
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摘要 目的:探讨正常大鼠肾上腺IL-10+细胞表达及其定位。方法:正常大鼠肾上腺,4%多聚甲醛溶液固定,常规石蜡包埋,连续切片,IL-10免疫组化标记,观察IL-10+细胞的表达和定位。结果:在正常大鼠肾上腺皮质球状带和外束状带,可见散在或成堆存在的表达为弱阳性的IL-10+细胞。髓质IL-10+细胞的阳性颗粒沿胞膜下分布。在肾上腺纵切面的中间几张切片上,可看到髓质IL-10+细胞从肾上腺髓质的一端伸出,往皮质延伸直至被膜。结论:正常大鼠肾上腺皮质和髓质确实存在IL-10表达阳性细胞。 Objective： To explore the expression and location of interleukin-lO in normal rat adrenal gland. Methods： Adrenal gland immunostaining with IL-10 marker were observed. Results： It is thus clear that IL-10＋ cells were distributed in zona glomerulosa and outside of zona faseieulata and there were several IL-10＋ cells from borders of medulla extending to capsule through cortex. Conclusion： There are IL-10＋ cells in normal rat adrenal cortex and medulla.
作者 林卡莉 黄志华 陈方
机构地区 赣南医学院基础医学院 赣南医学院
出处 《赣南医学院学报》 2009年第1期1-3,共3页 JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词 大鼠 肾上腺 IL-10 rat adrenal gland IL-10
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献9

  • 1Smith EM, Cadet P, Stefano GB, et al. IL-10 as a mdiator in the HPA axis and brain [ J ]. J Neuroimmunol, 1999,100( 1 -2) :140 - 148.
  • 2Peng H, Myers J, Fang X, et al . Integrative nuclear FG- FR1 signaling (INFS) pathway mediates activation of the tyrosine hydroxylase gene by angiotensin II, depolarization and protein kinase C[J]. J Neurochem, 2002,81 (3) : 506 - 524.
  • 3Bach LA, Leeding KS. Insulin-like growth factors decrease catecholamine content in PC12 rat pheochromocytoma cells[J]. Horm Metab Res, 2002,34(9):487-491.
  • 4Ziegler CG, Sicard F, Lattke P, et al: Dehydroepiandrosterone induces a neuroendocrine phenotype in nerve growth factor-stimulated chromaffin pheoehromocytoma PC12 cells [ J]. Endocrinology, 2008, 149 ( 1 ) : 320 - 328.
  • 5Wolf N, Krohn K, Bieger S, et al. Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary cells in vitro [ J ]. Neuroscience, 1999,90 ( 2 ) : 629 - 641.
  • 6Takekoshi K, Isobe K, Yashiro T, et al. Expression of vascular endothehal growth factor (VEGF) and its cognate receptors in human pheochromocytomas [ J ]. Life Sci, 2004,74(7) : 863 -871.
  • 7Ait-Ali D, Turquier V, Tanguy Y, et al. Tumor necrosis factor (TNF)-alpha persistently activates nuclear factor-kappaB signaling through the type 2 TNF receptor in chro- maffin cells: implications for long-term regulation of neuropeptide gene expression in inflammation [ J ]. Endocrinology, 2008,149 (6) :2840 - 2852.
  • 8Willenberg ItS, Ansurudeen I, Schebesta K, et al. The endothelium secretes interleukin-6 (IL-6) and induces IL- 6 and aldosterone generation by adrenocortical cells [ J ]. Exp Clin Endocrinol Diabetes, 2008, 116 ( 1 ) : 570 - 574.
  • 9邱一华,彭聿平,王建军.儿茶酚胺调节免疫功能的细胞和分子机制[J].生理科学进展,2003,34(4):303-308. 被引量：16

二级参考文献20

  • 1Gan X, Zhang L, Solomon GF, et al. Mechanism of norepi-nephrine-mediated inhibition of hnman NK cytotoxic functions: inhibition of cytokine secretion, target binding, and programming for cytotoxicity. Brain Behav Immun, 2002,16 : 227 -246.
  • 2Li CY, Chou TC, Lee CH, et al. Adrenaline inhibits lipopolysaccharide-induced macrophage inflammatory protein-1 alpha in human monocytes: the role of beta-adrenergic receptors. Anesth Analg, 2003, 96 : 518 -523.
  • 3Spengler NR, Alien RM, Remich DG, et al. Stimulation of alpha-adrenergic receptor augments the production of macrophage-defived tumor necrosis factor. J Immunl, 1990,145 : 1430 - 1434.
  • 4Kohm AP, Sanders VM. Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4 - T and B lymphocyte function in vitro and in vivo. Pharmacol Rev, 2001,53 : 487 - 525.
  • 5Kohm AP, Mozaffarian A, Sanders VM. B cell receptor-and beta 2-adrenergic receptor-induced regulation of B7-2(CD86) expression in B cells. J Immunol, 2002, 168 :6314 - 6322.
  • 6Sanders VM. The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2,and B lymphocyte function. Adv Exp Med Biol, 1998,437 : 269 - 278.
  • 7Fearon DT, I-ksley RM. The instructive role of innate immunity in the acquired immune response. Science,1996, 272 : 50 -53.
  • 8Zoukos Y, Thomaides TN, Kidd D, et al. Expression of beta 2 adrenoreceptors on peripheral blood mononuclear cells in patients with primary and secondary progressive multiple sclerosis: a longitudinal six month study. J Neurol Neurosurg Psychiatry, 2003, 74 : 197 - 202.
  • 9Stevenson JR, Westermann J, Liebmann PM, et al. Prolonged alpha-adrenergic stimulation causes changes in leukocyte distribution and lymphocyte apoptosis in the rat. J Neuroimmunol, 2001, 120 : 50 - 57.
  • 10Cupic V, Colic M, Pavicic L, et al. Immunomodulatory effect of xylazine, an alpha 2-adrenergic agonist, on rat spleen cells in culture. J Neuroimmunol, 2001, 113 : 19-29.

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赣南医学院学报
2009年 第1期

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