肝硬化患者血清胆碱酯酶活性、凝血酶原时间和白蛋白检测的临床应用

Clinical Practice of Detection of Serum Cholinesterase Activity,Prothrombin-time and Albumin in Patients with Liver Cirrhosis

目的：通过测定肝硬化患者血清胆碱酯酶活性（CHE）、凝血酶原时间（PT）和白蛋白（ALB）水平,探讨三者在肝硬化时的相互关系与临床意义。方法：对肝硬化患者血清胆碱酯酶活性、凝血酶原时间和血清白蛋白浓度进行检测,凝血酶原时间采用全自动血凝分析仪检测,血清胆碱酯酶以速率法测定,血清白蛋白浓度以溴甲酚绿法（BCG）在全自动分析仪上测定。结果：肝硬化患者血清胆碱酯酶活性、凝血酶原时间和白蛋白水平与正常对照组比较差异有显著性（P〈0.05）,三者彼此间相关系数为0.712-0.791（P〈0.01）,呈正相关。结论：监测血清胆碱酯酶、凝血酶原时间和白蛋白对肝硬化临床病情的判断及估计预后有着重要意义。

Objective：via the detection of serum cholinesterase activity, prothrombin time and albumin in cirrhotic patients , a further study can be hopefully done of the relationship between the three occurring to liver cirrhosis and its clinical significance. Methods： During the detection, coagulmometer is used to detect prothrombin time, rate method is applied to test serum cholinesterase and the density of serum albumin is checked by means of bromocresol green that is manipulated by automated chemistry analyzer. Result： Striking difference is shown（ P 〈 0.05 ） after the comparison is made between serum cholinesterase activity, prothromhin time and albumin in cirrhotic patients and the ones of the normal subjects, the correlative modulus between the three （ serum cholinesterase activity, prothrombin time and albumin） is 0.712 - 0.791 （ P 〈 0.01 ）, proving positive correlation. Conclusion ： To keep monitoring serum cholinesterase activity, prothrombin time and albumin is of great significance to the judgments on the clinical state as well as the estimation of the prognosis of liver cirrhosis.