癌症与血栓栓塞

Cancer and Thromboembolism

目前人们越来越多地认识到癌症患者具有较高的赢栓发生风险。动静脉血栓栓塞是癌症患者的常见弗发症。虽然其中的致病机理与多种因素有关，但是肿瘤细胞与宿主凝血系统的相互作用并使其激活乃是其中的主要原因。实验室检查证实了癌症患者处于一种血液高凝状态。抗凝治疗能够明是改善癌症的发病率和死亡率。目前。癌症患者血栓栓塞的新型防治措施正在研制之中。本文从病因学到治疗学等全方面回顾了血栓形成和癌症之间的复杂关系。

It becomes increasingly recognized that malignancy is associated with a significant risk of thrombosis. Venous and arterial thromboembolism is a common complication in patients with cancer. Although the pathogenesis of thrombosis in cancer is attributed to multifactors, the tumor cell capacity to interact with and activate the host blood coagulation system seems to play a prominent role. The laboratory tests confirm a prothrombotic state in cancer patients. The anticoagu- lant therapy can improve the morbidity and mortality of the underlying diseases. Recently, new approaches to prevention and treatment of thrombosis in caner have been on the way of development. In this article, we review the complex relationship, from pathogenesis to therapy, between thrombosis and cancer .