摘要
[目的]探讨轻亮胶囊对小鼠的抗辐射保护作用。[方法]用KM种小鼠连续14d给予0．35、0．70和1．40g／kg（分别相当于推荐人用量的5倍、10倍和20倍）轻亮胶囊灌胃，经3Gy^60Co—r射线辐照后，继续给予受试物至17-28d。检测小鼠的外周血及骨髓。[结果]受试物高剂量组能够明显对抗并减轻外周血白细胞数的减少（辐照3d升高57．1％；辐照14d升高61．1％）、骨髓有核细胞数的减少（抑制率由42．5％减少到22．8％）、微核细胞数的增多（抑制率为22．6％）和血清溶血素水平的降低（增加率31．6％）。[结论]轻亮胶囊具有抗辐射作用。
[Objective]To explore the antiradiation effect of Qingliang capsule on rats. [Methods]0.35 g/kg,0.70 g/kg and 1.40 g/kg （5,10 and 20 times as human recommended dosage） of Qingliang capsule were continuously given to rats of KM species for 14 d. The rats were radiated with 3Gy ^60Co-r,then Qing-liang capsule was given to rats for 17 d or 28 d. [Results]The decrease of peripheral blood leucocytes（57. 1% increase after 3 days radiation and 61.1 % increase after 14 days radiation）,bone marrow karyota（ inhabitation rate decreased from 42.5 % to 22.8%）, the increase of micronucleus cell（ inhabitation rate was 22.6%） and the decrease of serum haemogglutinin（ increasing rate was 31.6 %） in high dosage group, was obviously inhibited and slowed. [Conclusion]Qing-liang capsule had antiradiation effect.
出处
《预防医学论坛》
2009年第3期238-240,共3页
Preventive Medicine Tribune
关键词
轻亮胶囊
小鼠
抗辐射
白细胞
骨髓细胞
微核
溶血素
Qing-liang capsule
Rat
Antiradiation effect
white cell
Bone marrow cell
Micronucleus
Haemogglutinin
