摘要
Objective： To discuss the biodistribution of ^99mTc-Ciprofloxacin （^99mTc-CPF） and its effectiveness of imaging in infection disease in mice. Methods： CPF was labeled with ^99mTc and its radiochemical purity and labeling rate were measured. Mice model of infection was established and the biodistribution of ^99m Tc-CPF in the model and whole-body scintigraphy were achieved. Results： ^99mTc-Ciprotech was stable within 6 hours at room temperature. The labeling rate of ^99mTc-CPF was over 90%. Most of radioactivity was cleared in liver and kidney, and the clearance from blood was rapid. Both biodistribution and imaging results showed a high uptake of ^99mTc-CPF in infection site. The infection tissue/normal tissue reached a peak as 4.30 at 4 h after injection. Condusion： ^99mTc-CPF is a sensitive radiopharmaceutical agent for scintigraphy of infection lesions, and it is easy to prepare.
Objective:To discuss the biodistribution of99mTc-Ciprofloxacin(99mTc-CPF)and its effectiveness of imaging in infection disease in mice.Methods:CPF was labeled with99mTc and its radiochemical purity and labeling rate were measured.Mice model of infection was established and the biodistribution of99mTc-CPF in the model and whole-body scintigraphy were achieved.Results:99mTc-Ciprotech was stable within 6 hours at room temperature.The labeling rate of99mTc-CPF was over 90%.Most of radioactivity was cleared in liver and kidney,and the clearance from blood was rapid.Both biodistribution and imaging results showed a high uptake of99mTc-CPF in infection site.The infection tissue/normal tissue reached a peak as 4.30 at 4 h after injection.Conclusion:99mTc-CPF is a sensitive radiopharmaceutical agent for scintigraphy of infection lesions,and it is easy to prepare.
