脑梗死患者颈动脉粥样硬化斑块与血浆胆红素、尿酸的关系

Association of serum bilirubin and uric acid level with carotid plaque in patients with cerebral infarction

目的探讨脑梗死患者颈动脉粥样硬化斑块与血浆胆红素、尿酸的关系。方法对351例脑梗死患者行颈动脉彩色超声检查确定有无颈动脉斑块,根据斑块的有无分为颈动脉斑块组(n=218)和对照组(n=133)。检测两组患者血浆胆红素、尿酸,同时调查血糖、血脂、吸烟、酗酒、高血压等其他危险因素并比较分析。结果颈动脉斑块组血浆胆红素水平低于对照组,尿酸水平高于对照组,差异有统计学意义(P<0.05)。Logistic多元回归分析发现,血浆胆红素、尿酸均为脑梗死患者颈动脉粥样硬化斑块的独立危险因素。结论在脑梗死患者颈动脉斑块的发生发展中,血浆胆红素、尿酸起了非常重要的作用。

Objective To study the relationship between carotid plaque and serum bilirubin,uric acid in patients with cerebral infarction. Methods Three hundred and fifty-one in-patients with cerebral infarction were screened for carotid plaque by duplex color Doppler and then classified into plaque group （n=218） and control group （n=133） . The serum bilirubin and urie acid were measured. The other risk factors, such as serum glucose,lipids, smoking, drinking, hypertension were investigated . Results The levels of bilirubin were lower in carotid plaque group than those of control group. The levels of uric acid were higher in carotid plaque group. The result of logistic regression analysis indicated that serum bilirubin, uric acid were the inde- pendent risk factors. Conclusion Both serum bilirubin and uric acid are stongly and closely related to the occurance and development of carotid plaque in patients with cerebral infarction.