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胰岛素样生长因子结合蛋白2在胶质瘤中的表达及临床意义

Expression of Insulin-like Growth Factor Binding Protein 2 in Glioma:Related to Prognoses
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摘要 目的探讨不同病理分级胶质瘤中胰岛素样生长因子结合蛋白2(IGFBP-2)的表达情况,以及与其他分子及临床预后的相关性。方法应用免疫组化法检测45例不同病理分级胶质瘤组织中IGFBP-2的表达,并分析其表达与病理分级、肿瘤组织P53和Ki-67、患者预后的关系。结果IGFBP-2在肿瘤组织中的表达随肿瘤病理分级升高而升高,与P53和Ki-67的表达显著相关,肿瘤IGFBP-2表达高的患者复发期和总生存期均明显缩短。结论肿瘤组织IGFBP-2的表达情况是辅助胶质瘤诊断和预测预后的有效指标。 Objective To determine the levels of insulin-like growth factor binding protein-2 （IGFBP-2） in glioma tumor tissue and their clinical significance. Methods The levels of IGFBP 2 in glioma samples from 45 patients were detected with immunohisto- chemistry. Their correlation with tumor grade, p53 and Ki67 expression levels and the outcome of patients were tested. Results IG- FBP-2 increased in glioma tissue in a grade-dependent manner, and significantly correlated with p53 and Ki67 expression. High IG- FBP-2 level is significantly associated with earlier tumor recurrence and shorter overall survival. Conclusion Tumor IGFBP-2 levels can supply more prognostic information to the tumor grading system.
作者 崔云 徐丽 王军梅
机构地区 首都医科大学附属北京天坛医院
出处 《中国康复理论与实践》 CSCD 2009年第3期236-237,共2页 Chinese Journal of Rehabilitation Theory and Practice
关键词 胶质瘤 胰岛素样生长因子结合蛋白2(IGFBP-2) 预后 肿瘤分级 P53 KI-67 复发 生存期 glioma insulin-like growth factor binding protein-2 （IGFBP-2） prognosis tumor grade P53 Ki-67 recurrence survival
分类号 R730.264 [医药卫生—肿瘤]
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参考文献13

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中国康复理论与实践
2009年 第3期

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