脑钠尿肽在老年人非心脏手术后的变化及意义

Variance of Brain Natriuretic Peptide in Aged Patients after Noncardiac Surgery and Its Significance

目的探讨血浆脑钠尿肽(BNP)浓度在老年人非心脏手术后的变化及意义。方法依据术前血浆BNP浓度将101例择期行非心脏手术患者分为两组,A组(n=61):BNP浓度≤100ng/L;B组(n=40):BNP浓度>100ng/L,对比分析手术前后BNP浓度及术后心脏事件的发生情况。结果A组术前、术后BNP浓度分别为(58.2±28.7)ng/L、(53.7±25.9)ng/L(P>0.05);B组术前、术后BNP浓度分别为(147.3±72.1)ng/L、(341.5±92.4)ng/L(P<0.05)。A组无心脏事件发生,B组中有14例发生心脏事件(P<0.05)。结论术前血浆BNP浓度>100ng/L的老年人非心脏手术后血浆BNP浓度变化大,可能发生心脏事件。

Objective To explore the variance of plasma brain natriuretic peptide （BNP） concentrations in the aged patients after noncardiac surgery and its significance. Methods 101 patients undergoing elective noncardiac surgery were divided into two groups based on the BNP concentrations before surgery： group A： BNP≤100 ng/L, n： 613 group B1- BNP〉 100 ng/L, n= 40. The BNP concentrations before and after noncardiac surgery and the incidence of cardiac events in both groups were compared. Results There was no significant difference （P〈0.05） of BNP concentrations before and after noncardiac surgery in group A, which were （58.2± 28.7） ng/L and （53.7±25.9） ng/L respectively, but was significant difference （P〈0. 05） in group B, which were （147.3±72.1） ng/L and （341.55±92.4） ng/L respectively. There was significant difference （P〈0. 05） between group A, in which no patient happened cardiac event, and group B, in which 14 patients happened. Conclusion The plasma BNP concentration would be increased significantly in the aged patients with a BNP concentration〉100 ng/L before surgery, which may cause more cardiac events.