期刊文献+

阿托伐他汀对血脂正常高血压患者左室重构的影响 被引量:2

下载PDF
导出
摘要 目的:观察阿托伐他汀对血脂正常高血压患者血压及左室重构的影响。方法:58例血脂正常高血压患者分为对照组和治疗组。对照组29例用厄贝沙坦片(150mg/d),治疗组29例用厄贝沙坦片(150mg/d)加阿托伐他汀片(10mg/d),观察两组患者治疗前、治疗后6个月的左室舒张末内径(LVDD)、左室舒张末期室间隔厚度(IVST)、左室后壁厚度(LVPW)、左室重量指数(LVMI)及血压的变化。结果:治疗6个月后,与对照组比较,治疗组血压明显下降(P<0.05),IVST、LVPW和LVMI改善的程度更明显,有统计学意义(P<0.01)。结论:阿托伐他汀具有协同降压作用,阿托伐他汀能显著改善高血压患者左室重构。
出处 《实用医学杂志》 CAS 北大核心 2009年第6期963-964,共2页 The Journal of Practical Medicine
  • 相关文献

参考文献5

二级参考文献88

  • 1张铖,叶平,王兆君,张秀锦.阿托伐他汀对压力负荷增加引起大鼠心肌肥厚的影响[J].中国药学杂志,2005,40(4):271-273. 被引量:6
  • 2[3]Shokei Kim, Minoru Yoshiyama, Yasukatsu Izumi, et al. Effects of combination of ACE inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure. Circulation, 2001, 103: 148-154
  • 3[4]Taiji Matsusaka, Hideyuki Katori, Tadashi Inagami, et al. Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. J Clin Invest, 1999, 103: 1 451-458
  • 4[5]Manas Pathak, Sagartirtha Sarkar, Elangovan Vellaichamy, et al. Role of myocytes in myocardial collagen production. Hypertension, 2001, 37: 833-840
  • 5[6]Kazuhide Ogino, Bolin Cai, Anguo Gu, et al. Factors contributing to pressure overload-induced immediate early gene expression in adult rat hearts in vivo. Am J Physiol, 1999, 277 (1): H380-H387
  • 6[7]Shokei Kim, Hiroshi Iwao. Molecular and cellular mechanisms of angiotensin Ⅱ-mediated cardiovascular and renal diseases. Pharmacological Reviews, 2000, 52 (1): 11-34
  • 7[8]Shokei Kim, Kensuke Ohta, Akinori Hamaguchi, et al. Angiotensin Ⅱ induces cardiac phenotypic modulation and remodeling in vivo in rats. Hypertension, 1995, 25: 1 252-259
  • 8[9]Yu Liu, Annarosa Leri, Baosheng Li, et al. Angiotensin Ⅱ stimulation in vitro induces hypertrophy of normal and postinfarcted ventricular myocytes. Circulation Research, 1998, 82: 1 145-159
  • 9[10]Jorge P, van Kats, Danielle Methot, et al. Use of a biological peptide pump to study chronic peptide hormone action in transgenic mice: direct and indirect effects of angiotensin Ⅱ on the heart. J Biol Chem, 2001, 276 (47): 44 012-017
  • 10[11]Concepción Laviades, Nerea Varo, Javier Díez. Transforming growth factor? in hypertensives with cardiorenal damage. Hypertension, 2000, 36: 517-522

共引文献151

同被引文献11

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部