摘要
目的:探讨尿CystatinC在慢性肾脏病(CKD)中的诊断价值。方法:选择2006年12月～2007年12月我院住院CKD患者118例作为病例组,健康体检者20人为对照组,测定尿Cystatin C、24h尿蛋白定量、尿α1-微球蛋白(α1-MG)、尿白蛋白、尿转铁蛋白、尿IgG、血、尿β2-微球蛋白(β2-MG),并检测血清肌酐、白蛋白,计算MDRD-GFR。结果:尿Cys-tatin C与MDRD、血β2-MG、转铁蛋白、尿白蛋白、尿IgG没有相关性(P>0.05);尿Cystatin C与尿β2-MG、α1-MG、24h尿蛋白量有相关性;尿Cystatin C的受试者工作特征曲线下面积(AUCROC)>尿β2-MG的AUCROC。结论:尿Cystatin C不能反映GFR的减退,是肾小管损伤的敏感指标,在反映肾小管损伤方面优于尿β2-MG。
Objective：To evaluate the diagnostic value of urinary Cystatin C in patients with chronic kidney disease（CKD）. Methods： Between December 2006 and December 2007,118 patients with CKD from the Department of Nephrology, Shanghai Sixth People＇s Hospital were？ invovled as trial group, while 20 healthy persons were as control group. Urinary cystatin C,24 - hour urine protein, α1 - mieroglohulin（ α1 - MG） 、 microalbumin （ MA ） 、 Urinary transferring （ TF）, serum and urinary β2 microglobulin （ β2 - MG）, urinary IgG concentration were detected, serum creatinine and albumin were detected simultaneously. Estimate Glomerular filtration rate（eGFR） was estimated with equation of MDRD. Results：There was no correlation between urinary cystatin C and MDRD - GFR, Urinary TF, serum β2 - MG, MA, urinary IgG（ P 〉 0.05 ）. While urinary cystatin C was correlated with urinary β2 - MG, α1 - MG and 24 - hour urine protein;AUCROCof the urinary Cys C was larger than AUCRCof the urinary β2- MG. Conclusion. Urinary Cystatin C does not reflect the decrease of GFR. However, it is a more sensitive marker of tubular dysfunction compared with urinary β2 - microglobulin. KEY WORDS Chronic kidney disease Urinary cystatin C Urinary α1 - MG Urinary β2- MG
出处
《中国中西医结合肾病杂志》
2009年第3期220-222,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
