中枢神经细胞瘤的MRI表现与病理学基础

The MRI manifestations and pathological basis of central neurocytoma

目的:探讨中枢神经细胞瘤的MRI表现与病理学基础。方法:回顾性分析7例经病理证实的中枢神经细胞瘤患者的临床资料。结果:7例中枢神经细胞瘤位于侧脑室前2/3,邻近透明隔或Monro孔,形态不规则,可见分叶,边界清晰,MRI表现为T1WI呈等低或稍高信号,T2WI呈等或稍高信号,增强扫描见病灶呈不均匀轻中度强化,囊变和钙化区无强化。肿瘤大体上观察灰红色,质韧或软、血运丰富,其内可见囊变、钙化或出血。光镜下肿瘤细胞形态一致,细胞及细胞核小,圆形或卵圆形,胞浆浅染或透亮,核仁不明显,细胞排列呈盒状结构。免疫组化染色突触蛋白(SYN)及神经特异性烯醇化酶(NSE)阳性。结论:中枢神经细胞瘤MRI表现具备一定的特征性;病理学基础有助于理解该病的MRI表现。

Objective：To approach the Mill manifestations and pathological basis of central neurocytoma. Methods： MRI manifestations of 7 eases with the neurocytoma confirmed pathologically were analyzed retrospectively. Results： Central neurocytoma lesions were located in the anterior 2/3 of the lateral ventricle, either unilateral or bilateral, sometimes in the third ventricle, close to the septum pellucidum or monro＇s foramen. Most of them were irregularity, sublobe and sharpness of border. MRI T1WI could be equal, slightly low or slightly high signal. T2WI could be equal or slightly higher signal. Mass or cyst lesions were frequent, and calcification and bleeding could be seen. They showed inhomogeneous enhancement after intensified scanning. Generally, central neurocytomas were gray-red, tenacious or soft nature, abundance blood transportion; We can find the same cell shape, small and round cell nucleus, understain or lucency endochylema and box-shape cell order by light microscope, but we can＇t find the nucleolus; The synapsin and neurone specific enolase were masculine on Immunohistochemistry. Conclusion： Central neurocytoma lesions on MR/manifestations have the better characteristics; The pathological basis contributes to undstand the the MR/manifestations.